Circumventing the Henderson-Hasselbalch equation

Donald R. Kamens; Robert L. Wears; Cleve Trimble

doi:10.1016/S0361-1124(79)80061-1

Circumventing the Henderson-Hasselbalch equation

Donald R. Kamens^*, Robert L. Wears, Cleve Trimble

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Prompt blood-gas analysis consisting of pH, PCO₂, and PO₂ is now almost universally accessible. PCO₂ directly conveys the role of the respiratory mechanism in any acid-base disturbance. The metabolic condition, however, is hidden in a relationship between pH and PCO₂ that is most faithfully expressed by the cumbersome Henderson-Hasselbalch equation (HHE). Two methods of quickly determining metabolic status from pH and PCO₂, without resorting to the HHE, are discussed. The first method is well known and adjusts pH to represent only metabolic state by quantitatively cancelling the influence of hyper- or hypoventilation. The second method, not previously reported, uses measured pH to estimate the ratio HCO₃^-/PCO₂, which, when multiplied by PCO₂, equals bicarbonate ion concentration.

Original language	English
Pages (from-to)	462-466
Number of pages	5
Journal	Journal of the American College of Emergency Physicians
Volume	8
Issue number	11
DOIs	https://doi.org/10.1016/S0361-1124(79)80061-1
Publication status	Published - 1979
Externally published	Yes

Keywords

metabolism, blood-gas analysis

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10.1016/S0361-1124(79)80061-1

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title = "Circumventing the Henderson-Hasselbalch equation",

abstract = "Prompt blood-gas analysis consisting of pH, PCO2, and PO2 is now almost universally accessible. PCO2 directly conveys the role of the respiratory mechanism in any acid-base disturbance. The metabolic condition, however, is hidden in a relationship between pH and PCO2 that is most faithfully expressed by the cumbersome Henderson-Hasselbalch equation (HHE). Two methods of quickly determining metabolic status from pH and PCO2, without resorting to the HHE, are discussed. The first method is well known and adjusts pH to represent only metabolic state by quantitatively cancelling the influence of hyper- or hypoventilation. The second method, not previously reported, uses measured pH to estimate the ratio HCO3-/PCO2, which, when multiplied by PCO2, equals bicarbonate ion concentration.",

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T1 - Circumventing the Henderson-Hasselbalch equation

AU - Kamens, Donald R.

AU - Wears, Robert L.

AU - Trimble, Cleve

PY - 1979

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N2 - Prompt blood-gas analysis consisting of pH, PCO2, and PO2 is now almost universally accessible. PCO2 directly conveys the role of the respiratory mechanism in any acid-base disturbance. The metabolic condition, however, is hidden in a relationship between pH and PCO2 that is most faithfully expressed by the cumbersome Henderson-Hasselbalch equation (HHE). Two methods of quickly determining metabolic status from pH and PCO2, without resorting to the HHE, are discussed. The first method is well known and adjusts pH to represent only metabolic state by quantitatively cancelling the influence of hyper- or hypoventilation. The second method, not previously reported, uses measured pH to estimate the ratio HCO3-/PCO2, which, when multiplied by PCO2, equals bicarbonate ion concentration.

AB - Prompt blood-gas analysis consisting of pH, PCO2, and PO2 is now almost universally accessible. PCO2 directly conveys the role of the respiratory mechanism in any acid-base disturbance. The metabolic condition, however, is hidden in a relationship between pH and PCO2 that is most faithfully expressed by the cumbersome Henderson-Hasselbalch equation (HHE). Two methods of quickly determining metabolic status from pH and PCO2, without resorting to the HHE, are discussed. The first method is well known and adjusts pH to represent only metabolic state by quantitatively cancelling the influence of hyper- or hypoventilation. The second method, not previously reported, uses measured pH to estimate the ratio HCO3-/PCO2, which, when multiplied by PCO2, equals bicarbonate ion concentration.

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JO - Journal of the American College of Emergency Physicians

JF - Journal of the American College of Emergency Physicians

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ER -

Circumventing the Henderson-Hasselbalch equation

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