Clearance mechanisms of Alzheimer's amyloid-Β peptide

implications for therapeutic design and diagnostic tests

K. A. Bates, G. Verdile, Q. X. Li, D. Ames, P. Hudson, C. L. Masters, R. N. Martins

Research output: Contribution to journalReview article

164 Citations (Scopus)

Abstract

Currently, the amyloid hypothesis is the most widely accepted explanation for the pathogenesis of Alzheimer's disease (AD). According to this hypothesis, altered metabolism of the amyloid-Β (AΒ) peptide is central to the pathological cascade involved in the pathogenesis of AD. Although AΒ is produced by almost every cell in the body, a physiological function for the peptide has not been determined, and the pathways by which AΒ leads to cognitive dysfunction and cell death are unclear. Numerous therapeutic approaches that target the production, toxicity and removal of AΒ are being developed worldwide. Although therapeutic treatment for AD may be imminent, the value and effectiveness of such treatment are largely dependent on early diagnosis of the disease. This review summarizes current knowledge of AΒ clearance, transport and degradation, and evaluates the use of such information in the development of diagnostic tools. The conflicting results of plasma AΒ ELISAs are discussed, as are the more promising results of AΒ imaging by positron emission tomography. Current knowledge of AΒ-binding proteins and AΒ-degrading enzymes is analysed in the context of a potential therapy for AD. Transport across the blood-brain barrier by the receptor for advanced glycation end products and efflux via the multi-ligand lipoprotein receptor LRP-1 is also reviewed. Enhancing clearance and degradation of AΒ remains an attractive therapeutic strategy, and improved understanding of AΒ clearance may lead to advances in diagnostics and interventions designed to prevent or delay the onset of AD.

Original languageEnglish
Pages (from-to)469-486
Number of pages18
JournalMolecular Psychiatry
Volume14
Issue number5
DOIs
Publication statusPublished - May 2009
Externally publishedYes

Bibliographical note

Erratum can be found in Molecular Psychiatry, Volume 14(12), 1144, http://dx.doi.org/10.1038/mp.2008.123

Keywords

  • transport
  • apolipoprotein E
  • chaperone proteins
  • dementia
  • blood–brain barrier

Fingerprint Dive into the research topics of 'Clearance mechanisms of Alzheimer's amyloid-Β peptide: implications for therapeutic design and diagnostic tests'. Together they form a unique fingerprint.

Cite this