Abstract
Currently, the amyloid hypothesis is the most widely accepted explanation for the pathogenesis of Alzheimer's disease (AD). According to this hypothesis, altered metabolism of the amyloid-Β (AΒ) peptide is central to the pathological cascade involved in the pathogenesis of AD. Although AΒ is produced by almost every cell in the body, a physiological function for the peptide has not been determined, and the pathways by which AΒ leads to cognitive dysfunction and cell death are unclear. Numerous therapeutic approaches that target the production, toxicity and removal of AΒ are being developed worldwide. Although therapeutic treatment for AD may be imminent, the value and effectiveness of such treatment are largely dependent on early diagnosis of the disease. This review summarizes current knowledge of AΒ clearance, transport and degradation, and evaluates the use of such information in the development of diagnostic tools. The conflicting results of plasma AΒ ELISAs are discussed, as are the more promising results of AΒ imaging by positron emission tomography. Current knowledge of AΒ-binding proteins and AΒ-degrading enzymes is analysed in the context of a potential therapy for AD. Transport across the blood-brain barrier by the receptor for advanced glycation end products and efflux via the multi-ligand lipoprotein receptor LRP-1 is also reviewed. Enhancing clearance and degradation of AΒ remains an attractive therapeutic strategy, and improved understanding of AΒ clearance may lead to advances in diagnostics and interventions designed to prevent or delay the onset of AD.
Original language | English |
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Pages (from-to) | 469-486 |
Number of pages | 18 |
Journal | Molecular Psychiatry |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2009 |
Externally published | Yes |
Bibliographical note
Erratum can be found in Molecular Psychiatry, Volume 14(12), 1144, http://dx.doi.org/10.1038/mp.2008.123Keywords
- transport
- apolipoprotein E
- chaperone proteins
- dementia
- blood–brain barrier