Clearance of hepatitis C virus after newly acquired infection in injection drug users

Marianne Jauncey; Joanne M. Micallef; Stuart Gilmour; Janaki Amin; Peter A. White; William Rawlinson; John M. Kaldor; Ingrid van Beek; Gregory J. Dore

doi:10.1086/423943

Clearance of hepatitis C virus after newly acquired infection in injection drug users

Marianne Jauncey, Joanne M. Micallef, Stuart Gilmour, Janaki Amin, Peter A. White, William Rawlinson, John M. Kaldor, Ingrid van Beek, Gregory J. Dore^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Abstract

A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-HCV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA, with viral clearance defined as ≥2 consecutive negative HCV RNA test results after infection. Ninety-nine cases of HCV infection were identified; 57 had ≥2 HCV RNA test results after infection. Viral clearance occurred in 24 (42%) cases, with Kaplan-Meier estimated probabilities of 23%, 38%, and 40% at 6, 12, and 24 months, respectively.

Original language	English
Pages (from-to)	1270-1274
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	190
Issue number	7
DOIs	https://doi.org/10.1086/423943
Publication status	Published - 1 Oct 2004
Externally published	Yes

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10.1086/423943

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title = "Clearance of hepatitis C virus after newly acquired infection in injection drug users",

abstract = "A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-HCV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA, with viral clearance defined as ≥2 consecutive negative HCV RNA test results after infection. Ninety-nine cases of HCV infection were identified; 57 had ≥2 HCV RNA test results after infection. Viral clearance occurred in 24 (42\%) cases, with Kaplan-Meier estimated probabilities of 23\%, 38\%, and 40\% at 6, 12, and 24 months, respectively.",

author = "Marianne Jauncey and Micallef, \{Joanne M.\} and Stuart Gilmour and Janaki Amin and White, \{Peter A.\} and William Rawlinson and Kaldor, \{John M.\} and \{van Beek\}, Ingrid and Dore, \{Gregory J.\}",

year = "2004",

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doi = "10.1086/423943",

language = "English",

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T1 - Clearance of hepatitis C virus after newly acquired infection in injection drug users

AU - Jauncey, Marianne

AU - Micallef, Joanne M.

AU - Gilmour, Stuart

AU - Amin, Janaki

AU - White, Peter A.

AU - Rawlinson, William

AU - Kaldor, John M.

AU - van Beek, Ingrid

AU - Dore, Gregory J.

PY - 2004/10/1

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N2 - A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-HCV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA, with viral clearance defined as ≥2 consecutive negative HCV RNA test results after infection. Ninety-nine cases of HCV infection were identified; 57 had ≥2 HCV RNA test results after infection. Viral clearance occurred in 24 (42%) cases, with Kaplan-Meier estimated probabilities of 23%, 38%, and 40% at 6, 12, and 24 months, respectively.

AB - A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-HCV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA, with viral clearance defined as ≥2 consecutive negative HCV RNA test results after infection. Ninety-nine cases of HCV infection were identified; 57 had ≥2 HCV RNA test results after infection. Viral clearance occurred in 24 (42%) cases, with Kaplan-Meier estimated probabilities of 23%, 38%, and 40% at 6, 12, and 24 months, respectively.

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EP - 1274

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 7

ER -

Clearance of hepatitis C virus after newly acquired infection in injection drug users

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