Clinical challenges of a co-secreting TSH/GH pituitary adenoma

Hui Yi Ng, Divya Namboodiri, Diana Learoyd, Andrew Davidson, Bernard Champion, Veronica Preda

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Co-secreting thyrotropin/growth hormone (GH) pituitary adenomas are rare; their clinical presentation and long-term management are challenging. There is also a paucity of long-term data. Due to the cell of origin, these can behave as aggressive tumours. We report a case of a pituitary plurihormonal pit-1-derived macroadenoma, with overt clinical hyperthyroidism and minimal GH excess symptoms. The diagnosis was confirmed by pathology showing elevated thyroid and GH axes with failure of physiological GH suppression, elevated pituitary glycoprotein hormone alpha subunit (αGSU) and macroadenoma on imaging. Pre-operatively the patient was rendered euthyroid with carbimazole and underwent successful transphenoidal adenomectomy (TSA) with surgical cure. Histopathology displayed an elevated Ki-67 of 5.2%, necessitating long-term follow-up.

LanguageEnglish
Article number19-0068
Pages1-6
Number of pages6
JournalEndocrinology, Diabetes and Metabolism Case Reports
Volume2019
Issue number1
DOIs
Publication statusPublished - 17 Sep 2019

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Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone
Carbimazole
Alpha Subunit Glycoprotein Hormones
Thyrotropin
Hyperthyroidism
Thyroid Hormones
Pathology
Neoplasms

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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title = "Clinical challenges of a co-secreting TSH/GH pituitary adenoma",
abstract = "Co-secreting thyrotropin/growth hormone (GH) pituitary adenomas are rare; their clinical presentation and long-term management are challenging. There is also a paucity of long-term data. Due to the cell of origin, these can behave as aggressive tumours. We report a case of a pituitary plurihormonal pit-1-derived macroadenoma, with overt clinical hyperthyroidism and minimal GH excess symptoms. The diagnosis was confirmed by pathology showing elevated thyroid and GH axes with failure of physiological GH suppression, elevated pituitary glycoprotein hormone alpha subunit (αGSU) and macroadenoma on imaging. Pre-operatively the patient was rendered euthyroid with carbimazole and underwent successful transphenoidal adenomectomy (TSA) with surgical cure. Histopathology displayed an elevated Ki-67 of 5.2{\%}, necessitating long-term follow-up.",
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Clinical challenges of a co-secreting TSH/GH pituitary adenoma. / Ng, Hui Yi; Namboodiri, Divya; Learoyd, Diana; Davidson, Andrew; Champion, Bernard; Preda, Veronica.

In: Endocrinology, Diabetes and Metabolism Case Reports, Vol. 2019, No. 1, 19-0068, 17.09.2019, p. 1-6.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ng, Hui Yi

AU - Namboodiri, Divya

AU - Learoyd, Diana

AU - Davidson, Andrew

AU - Champion, Bernard

AU - Preda, Veronica

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