Clinical predictors of outcome from an Australian pharmacological relapse prevention trial

Kirsten C. Morley; Maree Teesson; Claudia Sannibale; Andrew Baillie; Paul S. Haber

doi:10.1093/alcalc/agq068

Clinical predictors of outcome from an Australian pharmacological relapse prevention trial

Kirsten C. Morley^*, Maree Teesson, Claudia Sannibale, Andrew Baillie, Paul S. Haber

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Aims: To assess which baseline characteristics of patients predict response to treatment with acamprosate (ACAMP) and naltrexone (NTX) in alcohol dependence. Methods: Outcome data from a 12-week randomized controlled trial of NTX, ACAMP and placebo for alcohol dependence were analysed by multiple logistic regression analyses to determine the predictive effects of gender and the baseline measures of dependence severity, craving, depression, anxiety and readiness to change in addition to NTX and ACAMP treatment. Moderators of the effect of each medication on outcomes were also examined. Results: Relapse was predicted by the interaction terms of ACAMP and alcohol dependence severity, NTX and depression as well as NTX and the readiness to change measure Taking Steps. Abstinence was similarly predicted by the interaction term ACAMP and alcohol dependence severity. Conclusion: The efficacy of NTX and ACAMP in reducing relapse or lapse is influenced by different clinical characteristics.

Original language	English
Article number	agq068
Pages (from-to)	520-526
Number of pages	7
Journal	Alcohol and Alcoholism
Volume	45
Issue number	6
DOIs	https://doi.org/10.1093/alcalc/agq068
Publication status	Published - 2010

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abstract = "Aims: To assess which baseline characteristics of patients predict response to treatment with acamprosate (ACAMP) and naltrexone (NTX) in alcohol dependence. Methods: Outcome data from a 12-week randomized controlled trial of NTX, ACAMP and placebo for alcohol dependence were analysed by multiple logistic regression analyses to determine the predictive effects of gender and the baseline measures of dependence severity, craving, depression, anxiety and readiness to change in addition to NTX and ACAMP treatment. Moderators of the effect of each medication on outcomes were also examined. Results: Relapse was predicted by the interaction terms of ACAMP and alcohol dependence severity, NTX and depression as well as NTX and the readiness to change measure Taking Steps. Abstinence was similarly predicted by the interaction term ACAMP and alcohol dependence severity. Conclusion: The efficacy of NTX and ACAMP in reducing relapse or lapse is influenced by different clinical characteristics.",

author = "Morley, {Kirsten C.} and Maree Teesson and Claudia Sannibale and Andrew Baillie and Haber, {Paul S.}",

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T1 - Clinical predictors of outcome from an Australian pharmacological relapse prevention trial

AU - Morley, Kirsten C.

AU - Teesson, Maree

AU - Sannibale, Claudia

AU - Baillie, Andrew

AU - Haber, Paul S.

PY - 2010

Y1 - 2010

N2 - Aims: To assess which baseline characteristics of patients predict response to treatment with acamprosate (ACAMP) and naltrexone (NTX) in alcohol dependence. Methods: Outcome data from a 12-week randomized controlled trial of NTX, ACAMP and placebo for alcohol dependence were analysed by multiple logistic regression analyses to determine the predictive effects of gender and the baseline measures of dependence severity, craving, depression, anxiety and readiness to change in addition to NTX and ACAMP treatment. Moderators of the effect of each medication on outcomes were also examined. Results: Relapse was predicted by the interaction terms of ACAMP and alcohol dependence severity, NTX and depression as well as NTX and the readiness to change measure Taking Steps. Abstinence was similarly predicted by the interaction term ACAMP and alcohol dependence severity. Conclusion: The efficacy of NTX and ACAMP in reducing relapse or lapse is influenced by different clinical characteristics.

AB - Aims: To assess which baseline characteristics of patients predict response to treatment with acamprosate (ACAMP) and naltrexone (NTX) in alcohol dependence. Methods: Outcome data from a 12-week randomized controlled trial of NTX, ACAMP and placebo for alcohol dependence were analysed by multiple logistic regression analyses to determine the predictive effects of gender and the baseline measures of dependence severity, craving, depression, anxiety and readiness to change in addition to NTX and ACAMP treatment. Moderators of the effect of each medication on outcomes were also examined. Results: Relapse was predicted by the interaction terms of ACAMP and alcohol dependence severity, NTX and depression as well as NTX and the readiness to change measure Taking Steps. Abstinence was similarly predicted by the interaction term ACAMP and alcohol dependence severity. Conclusion: The efficacy of NTX and ACAMP in reducing relapse or lapse is influenced by different clinical characteristics.

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U2 - 10.1093/alcalc/agq068

DO - 10.1093/alcalc/agq068

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Clinical predictors of outcome from an Australian pharmacological relapse prevention trial

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