Clinical review: Thyroid hormone replacement in children after cardiac surgery - Is it worth a try?

Nikolaus A. Haas*, Christoph K. Camphausen, Deniz Kececioglu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

Cardiac surgery using cardiopulmonary bypass produces a generalized systemic inflammatory response, resulting in increased postoperative morbidity and mortality. Under these circumstances, a typical pattern of thyroid abnormalities is seen in the absence of primary disease, defined as sick euthyroid syndrome (SES). The presence of postoperative SES mainly in small children and neonates exposed to long bypass times and the pharmacological profile of thyroid hormones and their effects on the cardiovascular physiology make supplementation therapy an attractive treatment option to improve postoperative morbidity and mortality. Many studies have been performed with conflicting results. In this article, we review the important literature on the development of SES in paediatric postoperative cardiac patients, analyse the existing information on thyroid hormone replacement therapy in this patient group and try to summarize the findings for a recommendation.

Original languageEnglish
Article number213
Pages (from-to)1-8
Number of pages8
JournalCritical Care
Volume10
Issue number3
DOIs
Publication statusPublished - 23 May 2006
Externally publishedYes

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