Abstract
Objective: To investigate the levels of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy at different stages.
Methods: A total of 80 patients with type 2 diabetes mellitus were enrolled in the present study. According to 24 h urinary albumin excretion ratio and renal function, they were further divided into group of diabetes without microalbuminuria (DN0, n = 20), microalbuminuria group (DN1, n = 20), macroalbuminuria group (DN2, n = 20) and renal insufficiency group (DN3, n = 20). Another 20 healthy subjects were enrolled as control group (non-DM). Plasma CD146 and P-selectin were measured by ELISA.
Results: Plasma CD146 and P-selectin were significantly increased in patients with type 2 diabetes with microalbuminuria (DN1) compared with health control (CD146: 415.3 ± 29.0 vs. 243.5 ± 14.7 ng/ml, P <0.05; P-selectin: 66.8 ± 3.4 vs. 45.3 ± 2.7 ng/ml, P <0.001). With the development of diabetic nephropathy, both plasma CD146 and P-selectin level progressively rise, with the highest levels in patients with significant renal insufficiency (DN3: 515.9 ± 36.9 and 81.5 ± 5.1 ng/ml respectively, P <0.001). Moreover, the increase in CD146 is positively co-related to the rise of P-selectin in patients with type 2 diabetes.
Conclusion: Expression of CD146 and P-selectin in patients with type 2 diabetes is elevated, and they are positively correlated with severity of diabetic nephropathy.
Original language | English |
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Pages (from-to) | 127-129 |
Number of pages | 3 |
Journal | Cytokine |
Volume | 57 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
Keywords
- CD146
- CRP
- Diabetic nephropathy
- P-selectin
- Type 2 diabetes mellitus