Clinically relevant phenotypes in chronic rhinosinusitis

Jessica W. Grayson*, Marina Cavada, Richard J. Harvey

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    28 Citations (Scopus)
    102 Downloads (Pure)


    Background: Chronic rhinosinusitis (CRS) is a complex disease that incorporates many different conditions. Currently, primary CRS is considered a disease of broad airway inflammation, however, the previous classification of CRS with and without nasal polyposis fails to adequately classify patients based upon their etiology of illness. Our aim with this review is discuss the clinical presentation, radiology, endoscopy, histopathology, and treatment algorithm of three different phenotypes of primary CRS: central compartment atopic disease, eosinophilic CRS, and non-eosinophilic CRS. Methods: A narrative review of a tertiary rhinology center's research themes and how they are applied to clinical protocols and practice was assessed. Discussion: Diagnosis and treatment of upper and lower airway conditions become increasingly important as phenotypes and endotypes are being described. There are well-described therapies to treat the different phenotypes of CRS, based upon the presumed underlying cause of the inflammatory process. Research continues to shed more light on different endotypes and phenotypes of airway inflammation, however, clinical differentiation of CRS can be applied in clinic practice with three simple phenotypes of CRS. Understanding these different phenotypes and their etiologies allows for further management beyond the maximum medical therapy and then surgery' approach that has often been used in the management of CRS.

    Original languageEnglish
    Article number23
    Pages (from-to)1-10
    Number of pages10
    JournalJournal of Otolaryngology - Head and Neck Surgery
    Issue number1
    Publication statusPublished - 29 May 2019

    Bibliographical note

    Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    A correction for this article has been published in Journal of Otolaryngology - Head & Neck Surgery (2019) 48:31, and can be found at


    • corticosteroid nasal irrigations
    • endoscopic sinus surgery
    • middle turbinate
    • asthma


    Dive into the research topics of 'Clinically relevant phenotypes in chronic rhinosinusitis'. Together they form a unique fingerprint.

    Cite this