Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice

Bettina Meiser, Peter R. Schofield, Lyndal Trevena, Alex Wilde, Kristine Barlow-Stewart, Judy Proudfoot, Michelle Peate, Timothy Dobbins, Helen Christensen, Kerry A. Sherman, Janan Karatas, Philip B. Mitchell

Research output: Contribution to journalArticleResearch

Abstract

Background: The strongest risk factor for depression is having a family history of the condition. Many individuals with a family history of depression are concerned about their personal risk for depression and report unmet educational and psychological support needs. No supportive and/or educational interventions are currently available that target this group of individuals. In this study we will develop and evaluate the first online psycho-educational intervention targeted to individuals with a family history of depression. Genetic risk information and evidence-rated information on preventive strategies for depression will be provided to such individuals in a general practice setting. The intervention will also incorporate a risk assessment tool. The content and delivery of the intervention will be pilot-tested.Methods/design: The proposed intervention will be evaluated in the general practitioner (GPs) setting, using a cluster randomized controlled trial. GP practices will be randomized to provide either access to the online, targeted psycho-educational intervention or brief generic information about depression (control) to eligible patients. Eligibility criteria include having at least one first-degree relative with either major depressive disorder (MDD) or bipolar disorder (BD). The primary outcome measure is 'intention to adopt, or actual adoption of, risk-reducing strategies'. Secondary outcome measures include: depression symptoms, perceived stigma of depression, knowledge of risk factors for development of depression and risk-reducing strategies, and perceived risk of developing depression or having a recurrence of family history. Over the course of the study, participants will complete online questionnaires at three time points: at baseline, and two weeks and six months after receiving the intervention or control condition.Discussion: This novel psycho-educational intervention will provide individuals with a family history of depression with information on evidence-based strategies for the prevention of depression, thus, we hypothesize, enabling them to make appropriate lifestyle choices and implement behaviors designed to reduce their risk for depression. The online psycho-educational intervention will also provide a model for similar interventions aimed at individuals at increased familial risk for other psychiatric disorders.Trial registration: The study is registered with the Australian and New Zealand Clinical Trials Group (Registration no: ACTRN12613000402741).

LanguageEnglish
Article number325
Pages1-10
Number of pages10
JournalBMC Psychiatry
Volume13
DOIs
Publication statusPublished - 1 Dec 2013

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General Practice
Randomized Controlled Trials
Depression
General Practitioners
Outcome Assessment (Health Care)
Choice Behavior
Major Depressive Disorder
New Zealand
Bipolar Disorder
Psychiatry
Life Style
Clinical Trials
Psychology
Recurrence

Bibliographical note

Copyright the Author(s) 2013. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Meiser, B., Schofield, P. R., Trevena, L., Wilde, A., Barlow-Stewart, K., Proudfoot, J., ... Mitchell, P. B. (2013). Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice. BMC Psychiatry, 13, 1-10. [325]. https://doi.org/10.1186/1471-244X-13-325
Meiser, Bettina ; Schofield, Peter R. ; Trevena, Lyndal ; Wilde, Alex ; Barlow-Stewart, Kristine ; Proudfoot, Judy ; Peate, Michelle ; Dobbins, Timothy ; Christensen, Helen ; Sherman, Kerry A. ; Karatas, Janan ; Mitchell, Philip B. / Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice. In: BMC Psychiatry. 2013 ; Vol. 13. pp. 1-10.
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Meiser, B, Schofield, PR, Trevena, L, Wilde, A, Barlow-Stewart, K, Proudfoot, J, Peate, M, Dobbins, T, Christensen, H, Sherman, KA, Karatas, J & Mitchell, PB 2013, 'Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice', BMC Psychiatry, vol. 13, 325, pp. 1-10. https://doi.org/10.1186/1471-244X-13-325

Cluster randomized controlled trial of a psycho-educational intervention for people with a family history of depression for use in general practice. / Meiser, Bettina; Schofield, Peter R.; Trevena, Lyndal; Wilde, Alex; Barlow-Stewart, Kristine; Proudfoot, Judy; Peate, Michelle; Dobbins, Timothy; Christensen, Helen; Sherman, Kerry A.; Karatas, Janan; Mitchell, Philip B.

In: BMC Psychiatry, Vol. 13, 325, 01.12.2013, p. 1-10.

Research output: Contribution to journalArticleResearch

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AU - Meiser, Bettina

AU - Schofield, Peter R.

AU - Trevena, Lyndal

AU - Wilde, Alex

AU - Barlow-Stewart, Kristine

AU - Proudfoot, Judy

AU - Peate, Michelle

AU - Dobbins, Timothy

AU - Christensen, Helen

AU - Sherman, Kerry A.

AU - Karatas, Janan

AU - Mitchell, Philip B.

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