Cobb Syndrome: A Case Report and Systematic Review of the Literature

Marissa Tubridy Clark, Emma L. Brooks, Winston Chong, Chris Pappas, Michael Fahey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T10-L5. This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.

Original languageEnglish
Pages (from-to)423-425
Number of pages3
JournalPediatric Neurology
Issue number6
Publication statusPublished - Dec 2008


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