TY - JOUR
T1 - Cobb Syndrome
T2 - A Case Report and Systematic Review of the Literature
AU - Tubridy Clark, Marissa
AU - Brooks, Emma L.
AU - Chong, Winston
AU - Pappas, Chris
AU - Fahey, Michael
PY - 2008/12
Y1 - 2008/12
N2 - We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T10-L5. This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.
AB - We report on a case of Cobb syndrome, a rare metameric disorder, characterized by a vascular abnormality of the spinal cord, with an associated vascular skin lesion of the same metamere, in an 8-year-old girl presenting with leg weakness. Magnetic resonance imaging revealed a spinal arteriovenous malformation at the level of T10-L5. This finding, together with a large, pigmented nevus at this level, is diagnostic for Cobb syndrome. A systematic review of the literature on Cobb syndrome, with a focus on treatment and outcomes, is presented. Current treatment options include combinations of embolization, neurosurgical intervention, corticosteroid therapy, and radiotherapy.
UR - http://www.scopus.com/inward/record.url?scp=56249141846&partnerID=8YFLogxK
U2 - 10.1016/j.pediatrneurol.2008.08.001
DO - 10.1016/j.pediatrneurol.2008.08.001
M3 - Article
C2 - 19027589
AN - SCOPUS:56249141846
VL - 39
SP - 423
EP - 425
JO - Pediatric Neurology
JF - Pediatric Neurology
SN - 0887-8994
IS - 6
ER -