Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees

Eirik Søvik, Pauline Berthier, William P. Klare, Paul Helliwell, Edwina L. S. Buckle, Jenny A. Plath, Andrew B. Barron, Ryszard Maleszka

Research output: Contribution to journalArticle

Abstract

Drug addiction is a chronic relapsing behavioral disorder. The high relapse rate has often been attributed to the perseverance of drug-associated memories due to high incentive salience of stimuli learnt under the influence of drugs. Drug addiction has also been interpreted as a memory disorder since drug associated memories are unusually enduring and some drugs, such as cocaine, interfere with neuroepigenetic machinery known to be involved in memory processing. Here we used the honey bee (an established invertebrate model for epigenomics and behavioral studies) to examine whether or not cocaine affects memory processing independently of its effect on incentive salience. Using the proboscis extension reflex training paradigm we found that cocaine strongly impairs consolidation of extinction memory. Based on correlation between the observed effect of cocaine on learning and expression of epigenetic processes, we propose that cocaine interferes with memory processing independently of incentive salience by directly altering DNA methylation dynamics. Our findings emphasize the impact of cocaine on memory systems, with relevance for understanding how cocaine can have such an enduring impact on behavior.

LanguageEnglish
Article number79
Pages1-11
Number of pages11
JournalFrontiers in Physiology
Volume9
Issue numberFEB
DOIs
StatePublished - 13 Feb 2018

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Honey
Bees
DNA Methylation
Cocaine
Brain
Motivation
Pharmaceutical Preparations
Substance-Related Disorders
Genetic Epigenesis
Memory Disorders
Invertebrates
Psychological Extinction
Epigenomics
Reflex
Learning
Recurrence

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

Søvik, E., Berthier, P., Klare, W. P., Helliwell, P., Buckle, E. L. S., Plath, J. A., ... Maleszka, R. (2018). Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees. Frontiers in Physiology, 9(FEB), 1-11. [79]. DOI: 10.3389/fphys.2018.00079
Søvik, Eirik ; Berthier, Pauline ; Klare, William P. ; Helliwell, Paul ; Buckle, Edwina L. S. ; Plath, Jenny A. ; Barron, Andrew B. ; Maleszka, Ryszard. / Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees. In: Frontiers in Physiology. 2018 ; Vol. 9, No. FEB. pp. 1-11
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Søvik, E, Berthier, P, Klare, WP, Helliwell, P, Buckle, ELS, Plath, JA, Barron, AB & Maleszka, R 2018, 'Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees' Frontiers in Physiology, vol 9, no. FEB, 79, pp. 1-11. DOI: 10.3389/fphys.2018.00079

Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees. / Søvik, Eirik; Berthier, Pauline; Klare, William P.; Helliwell, Paul; Buckle, Edwina L. S.; Plath, Jenny A.; Barron, Andrew B.; Maleszka, Ryszard.

In: Frontiers in Physiology, Vol. 9, No. FEB, 79, 13.02.2018, p. 1-11.

Research output: Contribution to journalArticle

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AU - Barron,Andrew B.

AU - Maleszka,Ryszard

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Søvik E, Berthier P, Klare WP, Helliwell P, Buckle ELS, Plath JA et al. Cocaine directly impairs memory extinction and alters brain DNA methylation dynamics in honey bees. Frontiers in Physiology. 2018 Feb 13;9(FEB):1-11. 79. Available from, DOI: 10.3389/fphys.2018.00079