Cognition in healthy aging is related to regional white matter integrity, but not cortical thickness

David A. Ziegler*, Olivier Piguet, David H. Salat, Keyma Prince, Emily Connally, Suzanne Corkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Citations (Scopus)


It is well established that healthy aging is accompanied by structural changes in many brain regions and functional decline in a number of cognitive domains. The goal of this study was to determine (1) whether the regional distribution of age-related brain changes is similar in gray matter (GM) and white matter (WM) regions, or whether these two tissue types are affected differently by aging, and (2) whether measures of cognitive performance are more closely linked to alterations in the cerebral cortex or in the underlying WM in older adults (OA). To address these questions, we collected high-resolution magnetic resonance imaging (MRI) data from a large sample of healthy young adults (YA; aged 18-28) and OA (aged 61-86 years). In addition, the OA completed a series of tasks selected to assess cognition in three domains: cognitive control, episodic memory, and semantic memory. Using advanced techniques for measuring cortical thickness and WM integrity, we found that healthy aging was accompanied by deterioration of both GM and WM, but with distinct patterns of change: Cortical thinning occurred primarily in primary sensory and motor cortices, whereas WM changes were localized to regions underlying association cortices. Further, in OA, we found a striking pattern of region-specific correlations between measures of cognitive performance and WM integrity, but not cortical thickness. Specifically, cognitive control correlated with integrity of frontal lobe WM, whereas episodic memory was related to integrity of temporal and parietal lobe WM. Thus, age-related impairments in specific cognitive capacities may arise from degenerative processes that affect the underlying connections of their respective neural networks.

Original languageEnglish
Pages (from-to)1912-1926
Number of pages15
JournalNeurobiology of Aging
Issue number11
Publication statusPublished - Nov 2010
Externally publishedYes


  • Aging
  • Cognitive control processes
  • Cortical thickness
  • DTI
  • Episodic memory
  • MRI
  • White matter


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