Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia

Maria Camila Gonzalez; Diego Alejandro Tovar-Rios; Guido Alves; Ingvild Dalen; Caroline H. Williams-Gray; Marta Camacho; Lars Forsgren; David Bäckström; Rachael A. Lawson; Angus D. Macleod; Carl E. Counsell; Claire Paquet; Carlo DeLena; Fabrizia D'Antonio; Andrea Pilotto; Alessandro Padovani; Frédéric Blanc; Cristian Falup-Pecurariu; Simon J. G. Lewis; Konrad Rejdak; Ewa Papuc; Jakub Hort; Zuzana Nedelska; John O'Brien; Laura Bonanni; Marta Marquié; Mercè Boada; Vanesa Pytel; Carla Abdelnour; Daniel Alcolea; Katrin Beyer; Ole Bjørn Tysnes; Dag Aarsland; Jodi Maple-Grødem

doi:10.1002/mdc3.13752

Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia

Maria Camila Gonzalez^*, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Bäckström, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frédéric Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad RejdakEwa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquié, Mercè Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole Bjørn Tysnes, Dag Aarsland, Jodi Maple-Grødem

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

Original language	English
Pages (from-to)	980-986
Number of pages	7
Journal	Movement Disorders Clinical Practice
Volume	10
Issue number	6
DOIs	https://doi.org/10.1002/mdc3.13752
Publication status	Published - Jun 2023
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

dementia with Lewy bodies
international cohort
Parkinson's disease dementia
parkinsonism
rate of cognitive decline

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10.1002/mdc3.13752Licence: CC BY

Publisher version (open access)Final published version, 436 KBLicence: CC BY

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Gonzalez, M. C., Tovar-Rios, D. A., Alves, G., Dalen, I., Williams-Gray, C. H., Camacho, M., Forsgren, L., Bäckström, D., Lawson, R. A., Macleod, A. D., Counsell, C. E., Paquet, C., DeLena, C., D'Antonio, F., Pilotto, A., Padovani, A., Blanc, F., Falup-Pecurariu, C., Lewis, S. J. G., ... Maple-Grødem, J. (2023). Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia. Movement Disorders Clinical Practice, 10(6), 980-986. https://doi.org/10.1002/mdc3.13752

@article{a888588870b84b0b95bff2d32eaff331,

title = "Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia",

abstract = "Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95\% CI −2.3, −1.3] vs. −1.9 [95\% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95\% CI 2.1, 7.5]) (PDD 4.8 [95\% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.",

keywords = "dementia with Lewy bodies, international cohort, Parkinson's disease dementia, parkinsonism, rate of cognitive decline",

author = "Gonzalez, \{Maria Camila\} and Tovar-Rios, \{Diego Alejandro\} and Guido Alves and Ingvild Dalen and Williams-Gray, \{Caroline H.\} and Marta Camacho and Lars Forsgren and David B{\"a}ckstr{\"o}m and Lawson, \{Rachael A.\} and Macleod, \{Angus D.\} and Counsell, \{Carl E.\} and Claire Paquet and Carlo DeLena and Fabrizia D'Antonio and Andrea Pilotto and Alessandro Padovani and Fr{\'e}d{\'e}ric Blanc and Cristian Falup-Pecurariu and Lewis, \{Simon J. G.\} and Konrad Rejdak and Ewa Papuc and Jakub Hort and Zuzana Nedelska and John O'Brien and Laura Bonanni and Marta Marqui{\'e} and Merc{\`e} Boada and Vanesa Pytel and Carla Abdelnour and Daniel Alcolea and Katrin Beyer and Tysnes, \{Ole Bj{\o}rn\} and Dag Aarsland and Jodi Maple-Gr{\o}dem",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = jun,

doi = "10.1002/mdc3.13752",

language = "English",

volume = "10",

pages = "980--986",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley \& Sons",

number = "6",

}

Gonzalez, MC, Tovar-Rios, DA, Alves, G, Dalen, I, Williams-Gray, CH, Camacho, M, Forsgren, L, Bäckström, D, Lawson, RA, Macleod, AD, Counsell, CE, Paquet, C, DeLena, C, D'Antonio, F, Pilotto, A, Padovani, A, Blanc, F, Falup-Pecurariu, C, Lewis, SJG, Rejdak, K, Papuc, E, Hort, J, Nedelska, Z, O'Brien, J, Bonanni, L, Marquié, M, Boada, M, Pytel, V, Abdelnour, C, Alcolea, D, Beyer, K, Tysnes, OB, Aarsland, D & Maple-Grødem, J 2023, 'Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia', Movement Disorders Clinical Practice, vol. 10, no. 6, pp. 980-986. https://doi.org/10.1002/mdc3.13752

TY - JOUR

T1 - Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia

AU - Gonzalez, Maria Camila

AU - Tovar-Rios, Diego Alejandro

AU - Alves, Guido

AU - Dalen, Ingvild

AU - Williams-Gray, Caroline H.

AU - Camacho, Marta

AU - Forsgren, Lars

AU - Bäckström, David

AU - Lawson, Rachael A.

AU - Macleod, Angus D.

AU - Counsell, Carl E.

AU - Paquet, Claire

AU - DeLena, Carlo

AU - D'Antonio, Fabrizia

AU - Pilotto, Andrea

AU - Padovani, Alessandro

AU - Blanc, Frédéric

AU - Falup-Pecurariu, Cristian

AU - Lewis, Simon J. G.

AU - Rejdak, Konrad

AU - Papuc, Ewa

AU - Hort, Jakub

AU - Nedelska, Zuzana

AU - O'Brien, John

AU - Bonanni, Laura

AU - Marquié, Marta

AU - Boada, Mercè

AU - Pytel, Vanesa

AU - Abdelnour, Carla

AU - Alcolea, Daniel

AU - Beyer, Katrin

AU - Tysnes, Ole Bjørn

AU - Aarsland, Dag

AU - Maple-Grødem, Jodi

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/6

Y1 - 2023/6

N2 - Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

AB - Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

KW - dementia with Lewy bodies

KW - international cohort

KW - Parkinson's disease dementia

KW - parkinsonism

KW - rate of cognitive decline

UR - https://www.scopus.com/pages/publications/85158093631

U2 - 10.1002/mdc3.13752

DO - 10.1002/mdc3.13752

M3 - Article

C2 - 37332651

AN - SCOPUS:85158093631

SN - 2330-1619

VL - 10

SP - 980

EP - 986

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 6

ER -

Cognitive and motor decline in dementia with Lewy bodies and Parkinson's disease dementia

Abstract

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Keywords

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