Cognitive deficits in neurofibromatosis 1

Kathryn North*, Shelley Hyman, Belinda Barton

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

81 Citations (Scopus)


Cognitive deficits and academic learning difficulties are the most common neurologic "complication" of neurofibromatosis 1 in childhood and can be responsible for significant lifetime morbidity. There is a slight increase in the frequency of mental retardation (Wechsler Full-Scale IQ < 70) in children with neurofibromatosis 1, but the mean Full-Scale IQ for the patient group is within 1 SD of the population mean. Academic difficulties are common, as are specific deficits in visuospatial ability, executive function, expressive and receptive language, and attentional skills. Behavioral and psychosocial problems have a major impact on quality of life, although there are few objective studies in this area. Current research is focusing on the pathogenesis of the disorder. Clinical studies have identified possible r diologic and pathologic markers for cognitive deficits in neurofibromatosis 1, which can now be explored in animal modes.

Original languageEnglish
Pages (from-to)605-612
Number of pages8
JournalJournal of Child Neurology
Issue number8
Publication statusPublished - 1 Aug 2002
Externally publishedYes


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