Cognitive dysfunction at baseline predicts symptomatic 1-year outcome in first-episode schizophrenics

Steffen Moritz*, Michael Krausz, Evelin Gottwalz, Martin Lambert, Christian Perro, Stefanie Ganzer, Dieter Naber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


The present study addresses the consequences of cognitive disturbances on symptomatic outcome. Fifty-three first-episode schizophrenics were reassessed (n = 32) 1 year after admission. Simple regression analyses revealed that several self-perceived cognitive deficits at baseline as measured with the Frankfurt Complaint Questionnaire significantly predicted increased Brief Psychiatric Rating Scale global scores at follow-up (p = 0.05 to p = 0.005). A stepwise regression analysis proved memory dysfunction to be the strongest predictor of symptomatic worsening (p = 0.005). It is suggested that the exploration and treatment of neuropsychological deficits in schizophrenia is of great clinical importance with regard to its impact on both functional and symptomatic outcome in schizophrenia.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
Issue number1
Publication statusPublished - Jan 2000
Externally publishedYes


  • Cognitive dysfunction
  • Prediction in schizophrenia
  • Schizophrenia


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