Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations

Jeffrey M. Rogers, Peter K. Panegyres*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

160 Citations (Scopus)


Cognitive impairment is common in multiple sclerosis (MS), occurring at all stages of the disease, and can be a major source of vocational disability, social impairment, and impoverished quality of life. Dysfunction in free recall from long-term memory, speed of information processing, working memory, and abstract reasoning are frequently observed in MS. Despite weak correlation with disease duration and physical disability status, the degree of cognitive impairment in MS has been related to the extent of topographically specific neuronal tissue damage and loss. Additional clinical factors including disease course, fatigue, affective disturbance, and medication can impact on the degree of MS-related cognitive impairment. We suggest that the symbol digits modalities test, paced auditory serial addition task, the clock drawing test and the MS neuropsychological screening questionnaire be considered as valid and relevant screening tests for cognitive impairment in MS.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalJournal of Clinical Neuroscience
Issue number10
Publication statusPublished - Oct 2007
Externally publishedYes


  • Cognitive impairment
  • Multiple sclerosis
  • Screening test


Dive into the research topics of 'Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations'. Together they form a unique fingerprint.

Cite this