Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 ) were conducted in 28 female PM-carriers (mean age: 41.32. ±. 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61. ±. 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.
- Cerebellar motor networks
- Cognitive-neuromotor interaction
- Fragile X Mental Retardation gene 1 (FMR1)
- Fragile X Mental Retardation protein (FMRP)
- Fragile X Tremor Ataxia Syndrome (FXTAS)
- Physiological Profile Assessment
- Postural control