TY - JOUR
T1 - Cognitive-motor interference during postural control indicates at-risk cerebellar profiles in females with the FMR1 premutation
AU - Kraan, Claudine M.
AU - Hocking, Darren R.
AU - Georgiou-Karistianis, Nellie
AU - Metcalfe, Sylvia A.
AU - Archibald, Alison D.
AU - Fielding, Joanne
AU - Trollor, Julian
AU - Bradshaw, John L.
AU - Cohen, Jonathan
AU - Cornish, Kim M.
PY - 2013/9/5
Y1 - 2013/9/5
N2 - Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 [39]) were conducted in 28 female PM-carriers (mean age: 41.32. ±. 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61. ±. 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.
AB - Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures from the Physiological Profile Assessment (Lord et al., 2003 [39]) were conducted in 28 female PM-carriers (mean age: 41.32. ±. 8.03) and 31 female controls with normal FMR1 alleles (mean age: 41.61. ±. 8.3). Multiple regression analyses were conducted to examine the moderating role of CGG-repeat length on the relation between age and postural sway under dual-task interference. In female PM-carriers, our results showed significantly poorer proprioceptive awareness, slower reaction time, and greater postural displacement when performing a concurrent verbal fluency task. Significantly, these findings showed age- and genetically-modulated changes in dual-task postural displacement in the medio-lateral direction in female PM-carriers. These findings highlight the sensitivity of postural control paradigms in identifying early cerebellar postural changes that may act as surrogate markers of future decline in female PM-carriers.
KW - Cerebellar motor networks
KW - Cognitive-neuromotor interaction
KW - Fragile X Mental Retardation gene 1 (FMR1)
KW - Fragile X Mental Retardation protein (FMRP)
KW - Fragile X Tremor Ataxia Syndrome (FXTAS)
KW - Physiological Profile Assessment
KW - Postural control
UR - http://www.scopus.com/inward/record.url?scp=84882788198&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2013.07.033
DO - 10.1016/j.bbr.2013.07.033
M3 - Article
C2 - 23896050
AN - SCOPUS:84882788198
SN - 0166-4328
VL - 253
SP - 329
EP - 336
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -