Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia

Loren Mowszowski, Daniel F. Hermens, Keri Diamond, Louisa Norrie, Nicole Cockayne, Philip B. Ward, Ian B. Hickie, Simon J G Lewis, Jennifer Batchelor, Sharon L. Naismith

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective: We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker of pre-attentive information processing, which in turn, is postulated to underpin higher-order cognitive processes. Methods: As part of a larger randomized controlled trial, forty 'at risk' (i.e., mild cognitive impairment or late-life depression) participants aged 51-79 years underwent neurophysiological, neuropsychological, and psychiatric assessments before and after a multi-faceted seven-week CT program or a 'treatment-as-usual' seven-week waitlist period. Results: The treatment group demonstrated significantly increased fronto-central MMN responses (p < 0.05), as well as improved phonemic verbal fluency (p < 0.05) and decreased self-rated memory difficulties (p < 0.05) following CT, in comparison to the waitlist control group. However, there were no significant correlations between enhanced MMN and cognitive/psychosocial outcomes. Conclusions: Results from this preliminary investigation indicate that CT is associated with enhanced neurophysiological mechanisms suggestive of improved pre-attentive processing, which may reflect alterations in underlying neurobiology. Further research is warranted to confirm these findings, to explicate whether CT is associated with restorative or compensatory neuroplastic processes and to determine whether MMN is a useful biomarker for treatment response.

LanguageEnglish
Pages1095-1108
Number of pages14
JournalJournal of Alzheimer's Disease
Volume41
Issue number4
DOIs
Publication statusPublished - 2014

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Neuronal Plasticity
Neurobiology
Automatic Data Processing
Cognition
Psychiatry
Dementia
Randomized Controlled Trials
Biomarkers
Depression
Education
Control Groups
Incidence
Research
Neuroprotection
Cognitive Dysfunction

Cite this

Mowszowski, L., Hermens, D. F., Diamond, K., Norrie, L., Cockayne, N., Ward, P. B., ... Naismith, S. L. (2014). Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia. Journal of Alzheimer's Disease, 41(4), 1095-1108. https://doi.org/10.3233/JAD-131985
Mowszowski, Loren ; Hermens, Daniel F. ; Diamond, Keri ; Norrie, Louisa ; Cockayne, Nicole ; Ward, Philip B. ; Hickie, Ian B. ; Lewis, Simon J G ; Batchelor, Jennifer ; Naismith, Sharon L. / Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia. In: Journal of Alzheimer's Disease. 2014 ; Vol. 41, No. 4. pp. 1095-1108.
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title = "Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia",
abstract = "Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective: We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker of pre-attentive information processing, which in turn, is postulated to underpin higher-order cognitive processes. Methods: As part of a larger randomized controlled trial, forty 'at risk' (i.e., mild cognitive impairment or late-life depression) participants aged 51-79 years underwent neurophysiological, neuropsychological, and psychiatric assessments before and after a multi-faceted seven-week CT program or a 'treatment-as-usual' seven-week waitlist period. Results: The treatment group demonstrated significantly increased fronto-central MMN responses (p < 0.05), as well as improved phonemic verbal fluency (p < 0.05) and decreased self-rated memory difficulties (p < 0.05) following CT, in comparison to the waitlist control group. However, there were no significant correlations between enhanced MMN and cognitive/psychosocial outcomes. Conclusions: Results from this preliminary investigation indicate that CT is associated with enhanced neurophysiological mechanisms suggestive of improved pre-attentive processing, which may reflect alterations in underlying neurobiology. Further research is warranted to confirm these findings, to explicate whether CT is associated with restorative or compensatory neuroplastic processes and to determine whether MMN is a useful biomarker for treatment response.",
author = "Loren Mowszowski and Hermens, {Daniel F.} and Keri Diamond and Louisa Norrie and Nicole Cockayne and Ward, {Philip B.} and Hickie, {Ian B.} and Lewis, {Simon J G} and Jennifer Batchelor and Naismith, {Sharon L.}",
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Mowszowski, L, Hermens, DF, Diamond, K, Norrie, L, Cockayne, N, Ward, PB, Hickie, IB, Lewis, SJG, Batchelor, J & Naismith, SL 2014, 'Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia', Journal of Alzheimer's Disease, vol. 41, no. 4, pp. 1095-1108. https://doi.org/10.3233/JAD-131985

Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia. / Mowszowski, Loren; Hermens, Daniel F.; Diamond, Keri; Norrie, Louisa; Cockayne, Nicole; Ward, Philip B.; Hickie, Ian B.; Lewis, Simon J G; Batchelor, Jennifer; Naismith, Sharon L.

In: Journal of Alzheimer's Disease, Vol. 41, No. 4, 2014, p. 1095-1108.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Cognitive training enhances pre-attentive neurophysiological responses in older adults 'at risk' of dementia

AU - Mowszowski, Loren

AU - Hermens, Daniel F.

AU - Diamond, Keri

AU - Norrie, Louisa

AU - Cockayne, Nicole

AU - Ward, Philip B.

AU - Hickie, Ian B.

AU - Lewis, Simon J G

AU - Batchelor, Jennifer

AU - Naismith, Sharon L.

PY - 2014

Y1 - 2014

N2 - Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective: We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker of pre-attentive information processing, which in turn, is postulated to underpin higher-order cognitive processes. Methods: As part of a larger randomized controlled trial, forty 'at risk' (i.e., mild cognitive impairment or late-life depression) participants aged 51-79 years underwent neurophysiological, neuropsychological, and psychiatric assessments before and after a multi-faceted seven-week CT program or a 'treatment-as-usual' seven-week waitlist period. Results: The treatment group demonstrated significantly increased fronto-central MMN responses (p < 0.05), as well as improved phonemic verbal fluency (p < 0.05) and decreased self-rated memory difficulties (p < 0.05) following CT, in comparison to the waitlist control group. However, there were no significant correlations between enhanced MMN and cognitive/psychosocial outcomes. Conclusions: Results from this preliminary investigation indicate that CT is associated with enhanced neurophysiological mechanisms suggestive of improved pre-attentive processing, which may reflect alterations in underlying neurobiology. Further research is warranted to confirm these findings, to explicate whether CT is associated with restorative or compensatory neuroplastic processes and to determine whether MMN is a useful biomarker for treatment response.

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