Collagen matrix as an inlay in endoscopic skull base reconstruction

G. M. Oakley, Jenna M. Christensen, M. Winder, B. P. Jonker, A. Davidson, T. Steel, C. Teo, R. J. Harvey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Multi-layer reconstruction has become standard in endoscopic skull base surgery. The inlay component used can vary among autografts, allografts, xenografts and synthetics, primarily based on surgeon preference. The short- and long-term outcomes of collagen matrix in skull base reconstruction are described. Methods: A case series of patients who underwent endoscopic skull base reconstruction with collagen matrix inlay were assessed. Immediate peri-operative outcomes (cerebrospinal fluid leak, meningitis, ventriculitis, intracranial bleeding, epistaxis, seizures) and delayed complications (delayed healing, meningoencephalocele, prolapse of reconstruction, delayed cerebrospinal fluid leak, ascending meningitis) were examined. Results: Of 120 patients (51.0 ± 17.5 years, 41.7 per cent female), peri-operative complications totalled 12.7 per cent (cerebrospinal fluid leak, 3.3 per cent; meningitis, 3.3 per cent; other intracranial infections, 2.5 per cent; intracranial bleeding, 1.7 per cent; epistaxis, 1.7 per cent; and seizures, 0 per cent). Delayed complications did not occur in any patients. Conclusion: Collagen matrix is an effective inlay material. It provides robust long-term separation between sinus and cranial cavities, and avoids donor site morbidity, but carries additional cost.

LanguageEnglish
Pages214-223
Number of pages10
JournalJournal of Laryngology and Otology
Volume132
Issue number3
DOIs
Publication statusPublished - Mar 2018

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Inlays
Skull Base
Meningitis
Epistaxis
Collagen
Cranial Sinuses
Seizures
Hemorrhage
Prolapse
Autografts
Heterografts
Allografts
Tissue Donors
Morbidity
Costs and Cost Analysis
Infection
Cerebrospinal Fluid Leak

Keywords

  • Collagen
  • Endoscopic Surgery
  • Skull Base

Cite this

Oakley, G. M. ; Christensen, Jenna M. ; Winder, M. ; Jonker, B. P. ; Davidson, A. ; Steel, T. ; Teo, C. ; Harvey, R. J. / Collagen matrix as an inlay in endoscopic skull base reconstruction. In: Journal of Laryngology and Otology. 2018 ; Vol. 132, No. 3. pp. 214-223.
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abstract = "Background: Multi-layer reconstruction has become standard in endoscopic skull base surgery. The inlay component used can vary among autografts, allografts, xenografts and synthetics, primarily based on surgeon preference. The short- and long-term outcomes of collagen matrix in skull base reconstruction are described. Methods: A case series of patients who underwent endoscopic skull base reconstruction with collagen matrix inlay were assessed. Immediate peri-operative outcomes (cerebrospinal fluid leak, meningitis, ventriculitis, intracranial bleeding, epistaxis, seizures) and delayed complications (delayed healing, meningoencephalocele, prolapse of reconstruction, delayed cerebrospinal fluid leak, ascending meningitis) were examined. Results: Of 120 patients (51.0 ± 17.5 years, 41.7 per cent female), peri-operative complications totalled 12.7 per cent (cerebrospinal fluid leak, 3.3 per cent; meningitis, 3.3 per cent; other intracranial infections, 2.5 per cent; intracranial bleeding, 1.7 per cent; epistaxis, 1.7 per cent; and seizures, 0 per cent). Delayed complications did not occur in any patients. Conclusion: Collagen matrix is an effective inlay material. It provides robust long-term separation between sinus and cranial cavities, and avoids donor site morbidity, but carries additional cost.",
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Collagen matrix as an inlay in endoscopic skull base reconstruction. / Oakley, G. M.; Christensen, Jenna M.; Winder, M.; Jonker, B. P.; Davidson, A.; Steel, T.; Teo, C.; Harvey, R. J.

In: Journal of Laryngology and Otology, Vol. 132, No. 3, 03.2018, p. 214-223.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Teo, C.

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