Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD

Ayushi Purohit; Bharti Kandiyal; Shakti Kumar; Agila Kumari Pragasam; Parul Kamboj; Daizee Talukdar; Jyoti Verma; Vipin Sharma; Soumalya Sarkar; Dinesh Mahajan; Rajni Yadav; Riya Ahmed; Ranjan Nanda; Madhu Dikshit; Sanjay K. Banerjee; null Shalimar; Bhabatosh Das

doi:10.1016/j.isci.2023.108764

Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD

Ayushi Purohit, Bharti Kandiyal, Shakti Kumar, Agila Kumari Pragasam, Parul Kamboj, Daizee Talukdar, Jyoti Verma, Vipin Sharma, Soumalya Sarkar, Dinesh Mahajan, Rajni Yadav, Riya Ahmed, Ranjan Nanda, Madhu Dikshit, Sanjay K. Banerjee, Shalimar, Bhabatosh Das

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bi-directional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions, and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD.

Original language	English
Article number	108764
Pages (from-to)	1-23
Number of pages	24
Journal	iScience
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.isci.2023.108764
Publication status	Published - 16 Feb 2024
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Human metabolism
Microbiology

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10.1016/j.isci.2023.108764Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 7.07 MBLicence: CC BY-NC-ND

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Purohit, A., Kandiyal, B., Kumar, S., Pragasam, A. K., Kamboj, P., Talukdar, D., Verma, J., Sharma, V., Sarkar, S., Mahajan, D., Yadav, R., Ahmed, R., Nanda, R., Dikshit, M., Banerjee, S. K., Shalimar, & Das, B. (2024). Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD. iScience, 27(2), 1-23. Article 108764. https://doi.org/10.1016/j.isci.2023.108764

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title = "Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD",

abstract = "Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bi-directional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions, and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD.",

keywords = "Human metabolism, Microbiology",

author = "Ayushi Purohit and Bharti Kandiyal and Shakti Kumar and Pragasam, {Agila Kumari} and Parul Kamboj and Daizee Talukdar and Jyoti Verma and Vipin Sharma and Soumalya Sarkar and Dinesh Mahajan and Rajni Yadav and Riya Ahmed and Ranjan Nanda and Madhu Dikshit and Banerjee, {Sanjay K.} and Shalimar and Bhabatosh Das",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2024",

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day = "16",

doi = "10.1016/j.isci.2023.108764",

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Purohit, A, Kandiyal, B, Kumar, S, Pragasam, AK, Kamboj, P, Talukdar, D, Verma, J, Sharma, V, Sarkar, S, Mahajan, D, Yadav, R, Ahmed, R, Nanda, R, Dikshit, M, Banerjee, SK, Shalimar & Das, B 2024, 'Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD', iScience, vol. 27, no. 2, 108764, pp. 1-23. https://doi.org/10.1016/j.isci.2023.108764

TY - JOUR

T1 - Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD

AU - Purohit, Ayushi

AU - Kandiyal, Bharti

AU - Kumar, Shakti

AU - Pragasam, Agila Kumari

AU - Kamboj, Parul

AU - Talukdar, Daizee

AU - Verma, Jyoti

AU - Sharma, Vipin

AU - Sarkar, Soumalya

AU - Mahajan, Dinesh

AU - Yadav, Rajni

AU - Ahmed, Riya

AU - Nanda, Ranjan

AU - Dikshit, Madhu

AU - Banerjee, Sanjay K.

AU - Shalimar, null

AU - Das, Bhabatosh

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2024/2/16

Y1 - 2024/2/16

N2 - Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bi-directional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions, and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD.

AB - Non-alcoholic fatty liver disease (NAFLD) is an emerging global health problem and a potential risk factor for metabolic diseases. The bi-directional interactions between liver and gut made dysbiotic gut microbiome one of the key risk factors for NAFLD. In this study, we reported an increased abundance of Collinsella aerofaciens in the gut of obese and NASH patients living in India. We isolated C. aerofaciens from the fecal samples of biopsy-proven NASH patients and observed that their genome is enriched with carbohydrate metabolism, fatty acid biosynthesis, and pro-inflammatory functions, and have the potency to increase ethanol level in blood. An animal study indicated that mice supplemented with C. aerofaciens had increased levels of circulatory ethanol, high levels of hepatic hydroxyproline, triglyceride, and inflammation in the liver. The present findings indicate that perturbation in the gut microbiome composition is a key risk factor for NAFLD.

KW - Human metabolism

KW - Microbiology

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SN - 2589-0042

VL - 27

SP - 1

EP - 23

JO - iScience

JF - iScience

IS - 2

M1 - 108764

ER -

Collinsella aerofaciens linked with increased ethanol production and liver inflammation contribute to the pathophysiology of NAFLD

Abstract

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