A transformative translational change programme to introduce genomics into healthcare: a complexity and implementation science study protocol

Natalie Taylor, Stephanie Best, Melissa Martyn, Janet C. Long, Kathryn N. North, Jeffrey Braithwaite, Clara Gaff

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction: Translating scientific advances in genomic medicine into evidence-based clinical practice is challenging. Studying the natural translation of genomics into 'early-adopting' health system sectors is essential. We will (a) examine 29 health systems (Australian and Melbourne Genomics Health Alliance flagships) integrating genomics into practice and (b) combine this learning to co-design and test an evidence-based generalisable toolkit for translating genomics into healthcare. Methods and analysis: Twenty-nine flagships integrating genomics into clinical settings are studied as complex adaptive systems to understand emergent and self-organising behaviours among inter-related actors and processes. The Effectiveness-Implementation Hybrid approach is applied to gather information on the delivery and potential for real-world implementation. Stages '1' and '2a' (representing hybrid model 1) are the focus of this protocol. The Translation Science to Population Impact (TSci Impact) framework is used to study policy decisions and service provision, and the Theoretical Domains Framework (TDF) is used to understand individual level behavioural change; both frameworks are applied across stages 1 and 2a. Stage 1 synthesises interview data from 32 participants involved in developing the genomics clinical practice systems and approaches across five 'demonstration-phase' (early adopter) flagships. In stage 2a, stakeholders are providing quantitative and qualitative data on process mapping, clinical audits, uptake and sustainability (TSci Impact), and psychosocial and environmental determinants of change (TDF). Findings will be synthesised before codesigning an intervention toolkit to facilitate implementation of genomic testing. Study methods to simultaneously test the comparative effectiveness of genomic testing and the implementation toolkit (stage 2b), and the refined implementation toolkit while simply observing the genomics intervention (stage 3) are summarised. Ethics and dissemination: Ethical approval has been granted. The results will be disseminated in academic forums and used to refine interventions to translate genomics evidence into healthcare. Non-traditional academic dissemination methods (eg, change in guidelines or government policy) will also be employed.

LanguageEnglish
Article numbere024681
Pages1-15
Number of pages15
JournalBMJ Open
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

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Genomics
Delivery of Health Care
Insurance Pools
Clinical Audit
Evidence-Based Practice
Health
Ethics
Population
Medicine
Learning
Guidelines
Interviews

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • behaviour change
  • complexity
  • genomics
  • implementation
  • sustainability
  • translation

Cite this

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A transformative translational change programme to introduce genomics into healthcare : a complexity and implementation science study protocol. / Taylor, Natalie; Best, Stephanie; Martyn, Melissa; Long, Janet C.; North, Kathryn N.; Braithwaite, Jeffrey; Gaff, Clara.

In: BMJ Open, Vol. 9, No. 3, e024681, 01.03.2019, p. 1-15.

Research output: Contribution to journalArticleResearchpeer-review

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