Common features between diabetes mellitus and Alzheimer's disease

J. Götz; L. M. Ittner; Y.-A. Lim

doi:10.1007/s00018-009-9070-1

Common features between diabetes mellitus and Alzheimer's disease

J. Götz^*, L. M. Ittner, Y.-A. Lim

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

97 Citations (Scopus)

Abstract

Epidemiological studies establish a link between Type 2 diabetes (T2DM) and Alzheimer's disease (AD), both leading causes of morbidity and mortality in the elderly. These diseases also share clinical and biochemical features suggesting common pathogenic mechanisms. Specifically, both are amyloidoses as they are characterized by fibrillar protein aggregates - amylin in T2DM pancreatic islets, and β-amyloid (Aβ) and neurofibrillary tangles (NFTs) in AD brain. Amylin aggregation is associated with pancreatic β-cell loss, and Aβ and NFT formation with neuronal cell loss. We discuss the possibility that amylin and Aβ exert their toxicity by similar mechanisms, with components of the pathocascades shared, and that therapies based on amyloidogenic properties are beneficial for both T2DM and AD.

Original language	English
Pages (from-to)	1321-1325
Number of pages	5
Journal	Cellular and Molecular Life Sciences
Volume	66
Issue number	8
DOIs	https://doi.org/10.1007/s00018-009-9070-1
Publication status	Published - 1 Apr 2009
Externally published	Yes

Keywords

β-Amyloid
Alzheimer's disease
Amylin
Tau
Type 2 diabetes mellitus

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10.1007/s00018-009-9070-1

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title = "Common features between diabetes mellitus and Alzheimer's disease",

abstract = "Epidemiological studies establish a link between Type 2 diabetes (T2DM) and Alzheimer's disease (AD), both leading causes of morbidity and mortality in the elderly. These diseases also share clinical and biochemical features suggesting common pathogenic mechanisms. Specifically, both are amyloidoses as they are characterized by fibrillar protein aggregates - amylin in T2DM pancreatic islets, and β-amyloid (Aβ) and neurofibrillary tangles (NFTs) in AD brain. Amylin aggregation is associated with pancreatic β-cell loss, and Aβ and NFT formation with neuronal cell loss. We discuss the possibility that amylin and Aβ exert their toxicity by similar mechanisms, with components of the pathocascades shared, and that therapies based on amyloidogenic properties are beneficial for both T2DM and AD.",

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T1 - Common features between diabetes mellitus and Alzheimer's disease

AU - Götz, J.

AU - Ittner, L. M.

AU - Lim, Y.-A.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Epidemiological studies establish a link between Type 2 diabetes (T2DM) and Alzheimer's disease (AD), both leading causes of morbidity and mortality in the elderly. These diseases also share clinical and biochemical features suggesting common pathogenic mechanisms. Specifically, both are amyloidoses as they are characterized by fibrillar protein aggregates - amylin in T2DM pancreatic islets, and β-amyloid (Aβ) and neurofibrillary tangles (NFTs) in AD brain. Amylin aggregation is associated with pancreatic β-cell loss, and Aβ and NFT formation with neuronal cell loss. We discuss the possibility that amylin and Aβ exert their toxicity by similar mechanisms, with components of the pathocascades shared, and that therapies based on amyloidogenic properties are beneficial for both T2DM and AD.

AB - Epidemiological studies establish a link between Type 2 diabetes (T2DM) and Alzheimer's disease (AD), both leading causes of morbidity and mortality in the elderly. These diseases also share clinical and biochemical features suggesting common pathogenic mechanisms. Specifically, both are amyloidoses as they are characterized by fibrillar protein aggregates - amylin in T2DM pancreatic islets, and β-amyloid (Aβ) and neurofibrillary tangles (NFTs) in AD brain. Amylin aggregation is associated with pancreatic β-cell loss, and Aβ and NFT formation with neuronal cell loss. We discuss the possibility that amylin and Aβ exert their toxicity by similar mechanisms, with components of the pathocascades shared, and that therapies based on amyloidogenic properties are beneficial for both T2DM and AD.

KW - β-Amyloid

KW - Alzheimer's disease

KW - Amylin

KW - Tau

KW - Type 2 diabetes mellitus

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DO - 10.1007/s00018-009-9070-1

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JO - Cellular and Molecular Life Sciences

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IS - 8

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Common features between diabetes mellitus and Alzheimer's disease

Abstract

Keywords

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