Comparative genomic analysis of glycoylation pathways in yeast, plants and higher eukaryotes

Shoba Ranganathan*, Sangdao Wongsai, K. M. Helena Nevalainen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)


N-linked glycosylation is an essential modification of secretory and membrane proteins in all eukaryotic cells. Here, we review the current metabolic pathways of N-linked oligosaccharide biosynthesis in the endoplasmic reticulum and in the Golgi apparatus for yeasts: Saccharomyces cerevisiae and Schizosaccharomyces pombe, and higher eukaryotes: plants and human. The evolutionarily conserved proteins, processed in the cytosolic and the luminal side of the ER membrane, and the unique genes and their specific functions, occurring in the Golgi complex, for each selected organism, will be collated and discussed. This precise knowledge of the glycosylation pathway contributes to better understanding of the N-linked glycoprotein biosynthesis among different species, resulting in the recently successfully engineered strains for heterologous gene expression systems for industrial and therapeutic protein production.

Original languageEnglish
Title of host publicationBioinformatics
EditorsDilip K. Arora, Randy M. Berka, Gautam B. Singh
Place of PublicationAmsterdam
Number of pages22
ISBN (Electronic)9780080463704
ISBN (Print)9780444518071
Publication statusPublished - 2006

Publication series

NameApplied mycology and biotechnology
ISSN (Print)1874-5334


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