Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Jane M. Carlton; John H. Adams; Joana C. Silva; Shelby L. Bidwell; Hernan Lorenzi; Elisabet Caler; Jonathan Crabtree; Samuel V. Angiuoli; Emilio F. Merino; Paolo Amedeo; Qin Cheng; Richard M R Coulson; Brendan S. Crabb; Hernando A. Del Portillo; Kobby Essien; Tamara V. Feldblyum; Carmen Fernandez-Becerra; Paul R. Gilson; Amy H. Gueye; Xiang Guo; Simon Kang'A; Taco W A Kooij; Michael Korsinczky; Esmeralda V S Meyer; Vish Nene; Ian Paulsen; Owen White; Stuart A. Ralph; Qinghu Ren; Tobias J. Sargeant; Steven L. Salzberg; Christian J. Stoeckert; Steven A. Sullivan; Marcio M. Yamamoto; Stephen L. Hoffman; Jennifer R. Wortman; Malcolm J. Gardner; Mary R. Galinski; John W. Barnwell; Claire M. Fraser-Liggett

doi:10.1038/nature07327

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Jane M. Carlton, John H. Adams, Joana C. Silva, Shelby L. Bidwell, Hernan Lorenzi, Elisabet Caler, Jonathan Crabtree, Samuel V. Angiuoli, Emilio F. Merino, Paolo Amedeo, Qin Cheng, Richard M R Coulson, Brendan S. Crabb, Hernando A. Del Portillo, Kobby Essien, Tamara V. Feldblyum, Carmen Fernandez-Becerra, Paul R. Gilson, Amy H. Gueye, Xiang GuoSimon Kang'A, Taco W A Kooij, Michael Korsinczky, Esmeralda V S Meyer, Vish Nene, Ian Paulsen, Owen White, Stuart A. Ralph, Qinghu Ren, Tobias J. Sargeant, Steven L. Salzberg, Christian J. Stoeckert, Steven A. Sullivan, Marcio M. Yamamoto, Stephen L. Hoffman, Jennifer R. Wortman, Malcolm J. Gardner, Mary R. Galinski, John W. Barnwell, Claire M. Fraser-Liggett

Research output: Contribution to journal › Article › peer-review

690 Citations (Scopus)

Abstract

The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Original language	English
Pages (from-to)	757-763
Number of pages	7
Journal	Nature
Volume	455
Issue number	7214
DOIs	https://doi.org/10.1038/nature07327
Publication status	Published - 9 Oct 2008

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Carlton, J. M., Adams, J. H., Silva, J. C., Bidwell, S. L., Lorenzi, H., Caler, E., Crabtree, J., Angiuoli, S. V., Merino, E. F., Amedeo, P., Cheng, Q., Coulson, R. M. R., Crabb, B. S., Del Portillo, H. A., Essien, K., Feldblyum, T. V., Fernandez-Becerra, C., Gilson, P. R., Gueye, A. H., ... Fraser-Liggett, C. M. (2008). Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature, 455(7214), 757-763. https://doi.org/10.1038/nature07327

@article{5cf5becf417f4420bbc4a62b4f5b2922,

title = "Comparative genomics of the neglected human malaria parasite Plasmodium vivax",

abstract = "The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.",

author = "Carlton, {Jane M.} and Adams, {John H.} and Silva, {Joana C.} and Bidwell, {Shelby L.} and Hernan Lorenzi and Elisabet Caler and Jonathan Crabtree and Angiuoli, {Samuel V.} and Merino, {Emilio F.} and Paolo Amedeo and Qin Cheng and Coulson, {Richard M R} and Crabb, {Brendan S.} and {Del Portillo}, {Hernando A.} and Kobby Essien and Feldblyum, {Tamara V.} and Carmen Fernandez-Becerra and Gilson, {Paul R.} and Gueye, {Amy H.} and Xiang Guo and Simon Kang'A and Kooij, {Taco W A} and Michael Korsinczky and Meyer, {Esmeralda V S} and Vish Nene and Ian Paulsen and Owen White and Ralph, {Stuart A.} and Qinghu Ren and Sargeant, {Tobias J.} and Salzberg, {Steven L.} and Stoeckert, {Christian J.} and Sullivan, {Steven A.} and Yamamoto, {Marcio M.} and Hoffman, {Stephen L.} and Wortman, {Jennifer R.} and Gardner, {Malcolm J.} and Galinski, {Mary R.} and Barnwell, {John W.} and Fraser-Liggett, {Claire M.}",

year = "2008",

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doi = "10.1038/nature07327",

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pages = "757--763",

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Carlton, JM, Adams, JH, Silva, JC, Bidwell, SL, Lorenzi, H, Caler, E, Crabtree, J, Angiuoli, SV, Merino, EF, Amedeo, P, Cheng, Q, Coulson, RMR, Crabb, BS, Del Portillo, HA, Essien, K, Feldblyum, TV, Fernandez-Becerra, C, Gilson, PR, Gueye, AH, Guo, X, Kang'A, S, Kooij, TWA, Korsinczky, M, Meyer, EVS, Nene, V, Paulsen, I, White, O, Ralph, SA, Ren, Q, Sargeant, TJ, Salzberg, SL, Stoeckert, CJ, Sullivan, SA, Yamamoto, MM, Hoffman, SL, Wortman, JR, Gardner, MJ, Galinski, MR, Barnwell, JW & Fraser-Liggett, CM 2008, 'Comparative genomics of the neglected human malaria parasite Plasmodium vivax', Nature, vol. 455, no. 7214, pp. 757-763. https://doi.org/10.1038/nature07327

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T1 - Comparative genomics of the neglected human malaria parasite Plasmodium vivax

AU - Carlton, Jane M.

AU - Adams, John H.

AU - Silva, Joana C.

AU - Bidwell, Shelby L.

AU - Lorenzi, Hernan

AU - Caler, Elisabet

AU - Crabtree, Jonathan

AU - Angiuoli, Samuel V.

AU - Merino, Emilio F.

AU - Amedeo, Paolo

AU - Cheng, Qin

AU - Coulson, Richard M R

AU - Crabb, Brendan S.

AU - Del Portillo, Hernando A.

AU - Essien, Kobby

AU - Feldblyum, Tamara V.

AU - Fernandez-Becerra, Carmen

AU - Gilson, Paul R.

AU - Gueye, Amy H.

AU - Guo, Xiang

AU - Kang'A, Simon

AU - Kooij, Taco W A

AU - Korsinczky, Michael

AU - Meyer, Esmeralda V S

AU - Nene, Vish

AU - Paulsen, Ian

AU - White, Owen

AU - Ralph, Stuart A.

AU - Ren, Qinghu

AU - Sargeant, Tobias J.

AU - Salzberg, Steven L.

AU - Stoeckert, Christian J.

AU - Sullivan, Steven A.

AU - Yamamoto, Marcio M.

AU - Hoffman, Stephen L.

AU - Wortman, Jennifer R.

AU - Gardner, Malcolm J.

AU - Galinski, Mary R.

AU - Barnwell, John W.

AU - Fraser-Liggett, Claire M.

PY - 2008/10/9

Y1 - 2008/10/9

N2 - The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

AB - The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

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U2 - 10.1038/nature07327

DO - 10.1038/nature07327

M3 - Article

C2 - 18843361

AN - SCOPUS:53649104458

SN - 0028-0836

VL - 455

SP - 757

EP - 763

JO - Nature

JF - Nature

IS - 7214

ER -

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

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