Comparative performance of transit time algorithms for non-invasive determination of segmental aortic pulse wave velocity from MRI blood flow signals

M. Butlin, S. Hickson, M. J. Graves, C. M. McEniery, A. P. Avolio, I. W. Wilkinson

    Research output: Contribution to journalMeeting abstractpeer-review

    Abstract

    Background. The availability of blood flow signals during MRI scanning allows measurement of segmental aortic pulse wave velocity (aPWV). However, because of the method of generating the flow velocity curve over several cardiac cycles and the smoothing algorithms affecting the initial onset of the wave, there is considerable variation in estimating pulse transit time. The aim of this study was to assess a range of mathematical algorithms for pulse transit time (PTT) calculation for comparative stability and repeatability. Methods. Seven algorithms (Table) were generated for PTT estimation from MRI aortic flow waveforms (10 subjects, 367 years, 4 male). Two measurements were recorded in each subject on different days for repeatability analysis. Outlier PWV results were classed as a “failed” measurement and the success rate calculated. Bland-Altman plots were constructed for each algorithm, and repeatability calculated. Agreement between different methods was calculated using repeated measures analysis. Results. Intersecting lines of fit during late diastole / early systole had the highest success rate followed by the phase-slope algorithm (99%; 98% respectively). Repeatability of measurement was highest using the phase-slope algorithm followed by the intersecting lines algorithm (standard deviation of differences 1.86; 2.22 m/s respectively). The intersecting lines algorithm had the best agreement with other pulse transit time algorithms. Conclusions. Whilst agreement between several PWV algorithms was high, no one algorithm was better in all categories. The intersecting lines algorithm was most robust and the phase-slope algorithm showed the greatest repeatability. These findings are imp
    Original languageEnglish
    Article number008
    Pages (from-to)1100
    Number of pages1
    JournalHypertension
    Volume53
    Issue number6
    Publication statusPublished - 2009
    Event30th Annual Scientific Meeting of the High Blood Pressure Research Council of Australia - Melbourne, Australia
    Duration: 3 Dec 20085 Dec 2008

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