Comparing the use of, and considering the need for, lumbar puncture in children with influenza or other respiratory virus infections

Gulam Khandaker, Leon Heron, Harunor Rashid, Jean Li-Kim-Moy, David Lester-Smith, Alison Kesson, Mary Mccaskill, Cheryl Jones, Yvonne Zurynski, Elizabeth J. Elliott, Dominic E. Dwyer, Robert Booy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
13 Downloads (Pure)

Abstract

Background: The clinical presentation of influenza in infancy may be similar to serious bacterial infection and be investigated with invasive procedures like lumbar puncture (LP), despite very limited evidence that influenza occurs concomitantly with bacterial meningitis, perhaps because the diagnosis of influenza is very often not established when the decision to perform LP is being considered. Methods: A retrospective medical record review was undertaken in all children presenting to the Children's Hospital at Westmead, Sydney, Australia, in one winter season with laboratory-confirmed influenza or other respiratory virus infections (ORVIs) but excluding respiratory syncytial virus, to compare the use of, and reflect on the need for, the performance of invasive diagnostic procedures, principally LP, but also blood culture, in influenza and non-influenza cases. We also determined the rate of concomitant bacterial meningitis or bacteraemia. Findings: Of 294 children, 51% had laboratory-confirmed influenza and 49% had ORVIs such as parainfluenza viruses (34%) and adenoviruses (15%). Of those with influenza, 18% had a LP and 71% had a blood culture performed compared with 6·3% and 55·5% in the ORVI group (for both P<0·01). In multivariate analysis, diagnosis of influenza was a strong independent predictor of both LP (P=0·02) and blood culture (P=0·05) being performed, and, in comparison with ORVIs, influenza cases were almost three times more likely to have a LP performed on presentation to hospital. One child with influenza (0·9%) had bacteraemia and none had meningitis. Interpretation: Children with influenza were more likely to undergo LP on presentation to hospital compared with those presenting with ORVIs. If influenza is confirmed on admission by near-patient testing, clinicians may be reassured and less inclined to perform LP, although if meningitis is clinically suspected, the clinician should act accordingly. We found that the risk of bacterial meningitis and bacteraemia was very low in hospitalised children with influenza and ORVIs. A systematic review should be performed to investigate this across a large number of settings.

Original languageEnglish
Pages (from-to)932-937
Number of pages6
JournalInfluenza and Other Respiratory Viruses
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Nov 2013
Externally publishedYes

Bibliographical note

Copyright the Publisher 2012. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Bacterial meningitis
  • Children
  • Influenza
  • Lumbar puncture
  • Respiratory viral infection

Fingerprint Dive into the research topics of 'Comparing the use of, and considering the need for, lumbar puncture in children with influenza or other respiratory virus infections'. Together they form a unique fingerprint.

Cite this