Comparison of an animal model of arteriovenous malformation with human arteriovenous malformation

Jian Tu, Athula Karunanayaka, Apsara Windsor, Marcus A. Stoodley*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    This study assessed the blood flow and histological changes of an animal model of arteriovenous malformation (AVM) over 84 days in 71 rats, and compared the histological findings to 17 specimens of human AVM. Carotid-jugular fistula blood flow positively correlated with time. The maximum flow rate occurred at 42 days, at which time the nidus was considered mature and was histologically similar to human AVMs. Morphological similarities between the model and human AVM vessels included heterogeneously thickened walls, splitting of the elastic lamina, thickened endothelial layers, endothelial cushions, lack of tight junctions, loss of endothelial continuity, endothelial-subendothelial adherent junctions, and luminally directed filopodia. These findings support the theory that vascular changes in human AVMs are secondary to increased flow and provide a basis for using this model in studies of AVMs.

    Original languageEnglish
    Pages (from-to)96-102
    Number of pages7
    JournalJournal of Clinical Neuroscience
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - Jan 2010

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