Comparison of clinical characteristics and management of inflammatory bowel disease in Hong Kong versus Melbourne

Lani Prideaux, Michael A. Kamm, Peter De Cruz, James Williams, Sally J. Bell, William R. Connell, Steven J. Brown, Mark Lust, Paul V. Desmond, Heyson Chan, Dorothy K L Chow, Justin C Y Wu, Rupert W. Leong, Joseph J. Sung, Francis K L Chan, Siew C. Ng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Background and Aim: Inflammatory bowel disease (IBD), common in Melbourne, was rare but is now increasing in incidence in Hong Kong (HK). To investigate whether these are the same diseases in the West and East, potential causes of changing incidence, and to plan resource needs, an appreciation of clinical characteristics in contrasting populations is essential. Methods: Disease characteristics were collected from prospectively populated IBD databases in two specialist centers in Melbourne, Australia and HK. Results: Of 795 patients (Crohn's disease [CD]:ulcerative colitis [UC] Melbourne 272:159 and HK 161:203), the age of diagnosis was higher, there were proportionally more male patients with CD but no UC sex difference, fewer patients were current or ex-smokers (CD 8% vs 50%; UC 17% vs 35%) and a family history of IBD was less common (2% vs 11%; P<0.001) in HK compared to Melbourne. Stricturing and perianal CD were more common in HK (12% vs 6%; P<0.001; and 29% vs 16%; P=0.001, respectively). In HK for UC, more patients had extensive disease at diagnosis (42% vs 22%) but colectomy was less common (7% vs 20%; P<0.001). In Melbourne there was greater steroid use at diagnosis and patients were more likely to receive an immunomodulator or anti-tumor necrosis factor agent. Conclusions: IBD in HK was diagnosed at an older age, and had more complicated disease behavior than in Melbourne. Medical therapy, however, was less intense in HK. These differences may relate to real differences in disease or delayed diagnosis due to late presentation and less disease recognition in HK.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number5
Publication statusPublished - 2012
Externally publishedYes


  • Asia
  • Crohn's disease
  • Ethnicity
  • Inflammatory bowel disease
  • Ulcerative colitis


Dive into the research topics of 'Comparison of clinical characteristics and management of inflammatory bowel disease in Hong Kong versus Melbourne'. Together they form a unique fingerprint.

Cite this