Comparison of isotope dilution and a portable anodic stripping voltammetry device for blood lead measurements

Source of lead in blood of female adults from Bangalore

Brian L. Gulson*, Thuppil Venkatesh, Jacqueline Palmer, Herman Suil D'Souza, Michael Korsch

*Corresponding author for this work

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    We have analyzed blood samples from 20 pregnant Indian women from the city of Bangalore to assess the suitability of Indian subjects in a pregnancy study and assess the feasibility of using the lead isotopic method for determining sources and pathways of lead in Indian subjects. Blood lead concentrations range from 4.3 to 20.1 μg dL-1 with a geometric mean of 9.0 μg dL-1. There is excellent agreement between the isotope dilution measurements for blood lead concentration and those obtained by anodic stripping voltammetry (ASV; R2 0.96, P < 0.0001). A paired t-test shows that there is a statistically significant difference (p 0.008) with the results for ASV being approximately 6% higher than for those obtained by isotope dilution. The 206pb/204pb ratios range from 17.12 to 17.75 and showed major differences to the lead isotopic ratios that have been measured in Indian lead-zinc mineral deposits. It is suggested that lead in petrol is a major source of lead in the blood of Bangalore women.

    Original languageEnglish
    Pages (from-to)979-982
    Number of pages4
    JournalAustralian Journal of Chemistry
    Volume57
    Issue number10
    DOIs
    Publication statusPublished - 2004

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