Complement-like protein from the phylogenetically primitive vertebrate,Eptatretus Stouti, is a Humoral Opsonin

David A. Raftos*, Jeffrey W. Hook, Robert L. Raison

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

1. 1. Serum from the Pacific hagfish,Eptatretus stouti,contains a complement-like protein (CLP). 2. 2. CLP from unfractionated hagfish serum and from affinity-purified preparations binds to yeast cell surfaces. 3. 3. Incubation with CLP enhances the phagocytosis of yeast by hagfish leukocytes. 4. 4. CLP-mediated opsonization can be inhibited by anti-CLP antibody, EDTA, d(+)mannose and l(+)rhamnose. 5. 5. Additional opsomic factors are also in hagfish serum.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalComparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology
Volume103
Issue number2
DOIs
Publication statusPublished - 1992
Externally publishedYes

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