Complete partial volume solution for ASL brain perfusion data applied to relapse remitting multiple sclerosis patients

Ruth Oliver, Linda Ly, Chenyu Wang, Heidi Beadnall, Ilaria Boscolo Galazzo, Michael Chappell, Xavier Golay, Enrico De Vita, David Thomas, Michael Barnett

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

ASL is a low resolution imaging modality that suffers from the partial volume effect, leading to an underestimation of GM perfusion. This effect has two principle causes; blurring from the point spread function in the slice direction, and inadequate resolution due to the need for large voxels to achieve sufficient SNR. Both may act as confounders for measurement of GM CBF abnormalities. Decreased GM perfusion could reflect neuronal loss or metabolic dysfunction; PV correction allows a decoupling of structure and function. We present the first application of a complete PV correction solution for ASL to a cohort of MS patients.

Original languageEnglish
Title of host publication24th ISMRM annual meeting and exhibition 2016 and 25th SMRT annual meeting 2016
Subtitle of host publicationproceedings
Place of PublicationConcord, CA
PublisherInternational Society for Magnetic Resonance in Medicine
Pages6804-6806
Number of pages3
Volume13
ISBN (Print)9781510837683
Publication statusPublished - 2017
Externally publishedYes
EventISMRM 24th Annual Meeting and Exhibition (2016) - , Singapore
Duration: 7 May 201613 May 2016
Conference number: 24th

Conference

ConferenceISMRM 24th Annual Meeting and Exhibition (2016)
CountrySingapore
Period7/05/1613/05/16

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