Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia

David B. Lovejoy, Des R. Richardson

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

The metal complexes of a variety of ligands show diverse pharmacological properties. The potential of these compounds as antineoplastic agents is underlined by the success of the clinically used platinum complex cisplatin (cis-[(NH3)2PtCl2]). In the current review, specific examples of gallium, copper, ruthenium and titanium complexes are discussed with special relevance to their use in the treatment of cancer. Some of these complexes have demonstrated marked activity in a number of animal models and for some compounds, clinical trials are anticipated or have already begun. Collectively, the results in the literature indicate that the study of metal complexes as antineoplastic agents deserves continued intensive investigation.

Original languageEnglish
Pages (from-to)1257-1270
Number of pages14
JournalExpert Opinion on Investigational Drugs
Volume9
Issue number6
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • anticancer agents
  • aroylhydrazones
  • chelators
  • gallium
  • metal complexes
  • thiosemicarbazones

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