Compositions and methods for treatment

Lars Ittner; Yazi Diana Ke

Compositions and methods for treatment

Lars Ittner (Inventor), Yazi Diana Ke (Inventor)

Research output: Patent

Abstract

Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.

Original language	English
Patent number	WO2021026601
IPC	C07K 14/ 47 A I,A61K 38/00 2006.1,A61P 25/28 2006.1
Priority date	1/06/20
Filing date	12/08/20
Publication status	Published - 18 Feb 2021

Access to Document

https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021026601

4 Patent

Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 22 Jun 2022, IPC No. C07K 14/ 47 A I, A61K 38/00, A61P 25/28, Patent No. EP4013773, Priority date 12 Aug 2019, Priority No. AU2019902892
Research output: Patent

Open Access
Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 3 Nov 2022, IPC No. A61P 25/ 28 A I, A61K 38/08, Patent No. US2022347258, 12 Aug 2020, Priority date 12 Aug 2019, Priority No. AU2019902892
Research output: Patent

Open Access
Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 3 Mar 2022, IPC No. C07K 14/ 47 A I, A61K 38/00, A61P 25/28, Patent No. AU2020331401, 12 Aug 2020, Priority date 12 Aug 2020, Priority No. WO2020AU50833
Research output: Patent

Open Access

Cite this

@misc{70ee9b06e8b9474cb069277befc66124,

title = "Compositions and methods for treatment",

abstract = "Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.",

author = "Lars Ittner and Ke, {Yazi Diana}",

year = "2021",

month = feb,

day = "18",

language = "English",

type = "Patent",

note = "WO2021026601; C07K 14/ 47 A I,A61K 38/00 2006.1,A61P 25/28 2006.1",

}

TY - PAT

T1 - Compositions and methods for treatment

AU - Ittner, Lars

AU - Ke, Yazi Diana

PY - 2021/2/18

Y1 - 2021/2/18

N2 - Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.

AB - Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.

M3 - Patent

M1 - WO2021026601

Y2 - 2020/08/12

ER -

Compositions and methods for treatment

Abstract

Access to Document

Fingerprint

Research output