Compositions and methods for treatment

Lars Ittner; Yazi Diana Ke

Compositions and methods for treatment

Lars Ittner (Inventor), Yazi Diana Ke (Inventor)

Research output: Patent

Abstract

Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.

Original language	English
Patent number	US2022347258
IPC	A61P 25/ 28 A I,A61K 38/08
Priority date	12/08/19
Filing date	12/08/20
Publication status	Published - 3 Nov 2022

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4 Patent

Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 22 Jun 2022, IPC No. C07K 14/ 47 A I, A61K 38/00, A61P 25/28, Patent No. EP4013773, Priority date 12 Aug 2019, Priority No. AU2019902892
Research output: Patent

Open Access
Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 3 Mar 2022, IPC No. C07K 14/ 47 A I, A61K 38/00, A61P 25/28, Patent No. AU2020331401, 12 Aug 2020, Priority date 12 Aug 2020, Priority No. WO2020AU50833
Research output: Patent

Open Access
Compositions and methods for treatment
Ittner, L. (Inventor) & Ke, Y. D. (Inventor), 18 Feb 2021, IPC No. C07K 14/ 47 A I, A61K 38/00 2006.1, A61P 25/28 2006.1, Patent No. WO2021026601, 12 Aug 2020, Priority date 1 Jun 2020, Priority No. AU20200901796
Research output: Patent

Open Access

Cite this

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AB - Provided herein are methods for treating or preventing, or ameliorating at least one symptom of, a neurodegenerative disease associated with TDP-43 pathology, comprising administering to a subject an effective amount of a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, optionally linked to a protein destabilization domain sequence, or a nucleic acid molecule encoding said peptide. Also provided is a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a conservative variant thereof, a chimeric molecule comprising said peptide linked to a protein destabilization domain sequence, and a polynucleotide encoding said peptide or chimeric molecule.

M3 - Patent

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Compositions and methods for treatment

Abstract

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