Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov.

Cameron L. M. Gilchrist, Heather J. Lacey, Daniel Vuong, John I. Pitt, Lene Lange, Ernest Lacey, Bo Pilgaard, Yit-Heng Chooi*, Andrew M. Piggott

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Aspergillus burnettii is a new species belonging to the A. alliaceus clade in Aspergillus subgenus Circumdati section Flavi isolated from peanut-growing properties in southern Queensland, Australia. A. burnettii is a fast-growing, floccose fungus with distinctive brown conidia and is a talented producer of biomass-degrading enzymes and secondary metabolites. Chemical profiling of A. burnettii revealed the metabolites ochratoxin A, kotanins, isokotanins, asperlicin E, anominine and paspalinine, which are common to subgenus Circumdati, together with burnettiene A, burnettramic acids, burnettides, and high levels of 14α-hydroxypaspalinine and hirsutide. The genome of A. burnettii was sequenced and an annotated draft genome is presented. A. burnettii is rich in secondary metabolite biosynthetic gene clusters, containing 51 polyketide synthases, 28 non-ribosomal peptide synthetases and 19 genes related to terpene biosynthesis. Functional annotation of digestive enzymes of A. burnettii and A. alliaceus revealed overlapping carbon utilisation profiles, consistent with a close phylogenetic relationship.

    Original languageEnglish
    Article number103435
    Pages (from-to)1-15
    Number of pages15
    JournalFungal Genetics and Biology
    Volume143
    DOIs
    Publication statusPublished - Oct 2020

    Keywords

    • Aspergillus
    • Biosynthetic gene cluster analysis
    • Carbohydrate active enzymes
    • Chemotaxonomy
    • Molecular phylogeny
    • Secondary metabolites

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