Computational analyses of arteriovenous malformations in neuroimaging

Antonio Di Ieva*, Mounir Boukadoum, Salim Lahmiri, Michael D. Cusimano

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)


Computational models have been investigated for the analysis of the physiopathology and morphology of arteriovenous malformation (AVM) in recent years. Special emphasis has been given to image fusion in multimodal imaging and 3-dimensional rendering of the AVM, with the aim to improve the visualization of the lesion (for diagnostic purposes) and the selection of the nidus (for therapeutic aims, like the selection of the region of interest for the gamma knife radiosurgery plan). Searching for new diagnostic and prognostic neuroimaging biomarkers, fractal-based computational models have been proposed for describing and quantifying the angioarchitecture of the nidus. Computational modeling in the AVM field offers promising tools of analysis and requires a strict collaboration among neurosurgeons, neuroradiologists, clinicians, computer scientists, and engineers. We present here some updated state-of-the-art exemplary cases in the field, focusing on recent neuroimaging computational modeling with clinical relevance, which might offer useful clinical tools for the management of AVMs in the future.

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalJournal of Neuroimaging
Issue number3
Publication statusPublished - 1 May 2015
Externally publishedYes


  • Angioarchitecture
  • Arteriovenous malformation
  • AVM
  • Computational modeling
  • Fractal analysis
  • Image biomarker
  • Neuroimaging
  • Segmentation

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