@inbook{df3c2fe6c7b3495fa8c13ad24f318938,
title = "Computational fractal-based analysis of MR susceptibility-weighted imaging (SWI) in neuro-oncology and neurotraumatology",
abstract = "Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique able to depict the magnetic susceptibility produced by different substances, such as deoxyhemoglobin, calcium, and iron. The main application of SWI in clinical neuroimaging is detecting microbleedings and venous vasculature. Quantitative analyses of SWI have been developed over the last few years, aimed to offer new parameters, which could be used as neuroimaging biomarkers. Each technique has shown pros and cons, but no gold standard exists yet. The fractal dimension (FD) has been investigated as a novel potential objective parameter for monitoring intratumoral space-filling properties of SWI patterns. We showed that SWI patterns found in different tumors or different glioma grades can be represented by a gradient in the fractal dimension, thereby enabling each tumor to be assigned a specific SWI fingerprint. Such results were especially relevant in the differentiation of low-grade versus high-grade gliomas, as well as from malignant gliomas versus lymphomas. Therefore FD has been suggested as a potential image biomarker to analyze intrinsic neoplastic architecture in order to improve the differential diagnosis within clinical neuroimaging, determine appropriate therapy, and improve outcome in patients. These promising preliminary findings could be extended into the field of neurotraumatology, by means of the application of computational fractal-based analyses for the qualitative and quantitative imaging of microbleedings in traumatic brain injury patients. In consideration of some evidences showing that SWI signals are correlated with trauma clinical severity, FD might offer some objective prognostic biomarkers. In conclusion, fractal-based morphometrics of SWI could be further investigated to be used in a complementary way with other techniques, in order to form a holistic understanding of the temporal evolution of brain tumors and follow-up response to treatment, with several further applications in other fields, such as neurotraumatology and cerebrovascular neurosurgery as well.",
keywords = "brain tumors, fractal dimension, SWI, susceptibility-weighted imaging, traumatic brain injury",
author = "{Di Ieva}, Antonio",
year = "2016",
doi = "10.1007/978-1-4939-3995-4_20",
language = "English",
isbn = "9781493939954",
series = "Springer Series in Computational Neuroscience",
publisher = "Springer, Springer Nature",
pages = "311--332",
editor = "{Di Ieva}, Antonio",
booktitle = "The Fractal geometry of the brain",
address = "United States",
}