Computational imaging reveals shape differences between normal and malignant prostates on MRI

Mirabela Rusu; Andrei S. Purysko; Sadhna Verma; Jonathan Kiechle; Jay Gollamudi; Soumya Ghose; Karin Herrmann; Vikas Gulani; Raj Paspulati; Lee Ponsky; Maret Bohm; Anne Maree Haynes; Daniel Moses; Ron Shnier; Warick Delprado; James T. Thompson; Phillip D. Stricker; Anant Madabhushi

doi:10.1038/srep41261

Computational imaging reveals shape differences between normal and malignant prostates on MRI

Mirabela Rusu, Andrei S. Purysko, Sadhna Verma, Jonathan Kiechle, Jay Gollamudi, Soumya Ghose, Karin Herrmann, Vikas Gulani, Raj Paspulati, Lee Ponsky, Maret Bohm, Anne Maree Haynes, Daniel Moses, Ron Shnier, Warick Delprado, James T. Thompson, Phillip D. Stricker, Anant Madabhushi

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Abstract

We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p <0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.

Original language	English
Article number	41261
Pages (from-to)	1-11
Number of pages	11
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/srep41261
Publication status	Published - 1 Feb 2017
Externally published	Yes

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Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Rusu, M., Purysko, A. S., Verma, S., Kiechle, J., Gollamudi, J., Ghose, S., Herrmann, K., Gulani, V., Paspulati, R., Ponsky, L., Bohm, M., Haynes, A. M., Moses, D., Shnier, R., Delprado, W., Thompson, J. T., Stricker, P. D., & Madabhushi, A. (2017). Computational imaging reveals shape differences between normal and malignant prostates on MRI. Scientific Reports, 7, 1-11. Article 41261. https://doi.org/10.1038/srep41261

@article{6e3936570ff84f8a8d908540284dc201,

title = "Computational imaging reveals shape differences between normal and malignant prostates on MRI",

abstract = "We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p <0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.",

author = "Mirabela Rusu and Purysko, {Andrei S.} and Sadhna Verma and Jonathan Kiechle and Jay Gollamudi and Soumya Ghose and Karin Herrmann and Vikas Gulani and Raj Paspulati and Lee Ponsky and Maret Bohm and Haynes, {Anne Maree} and Daniel Moses and Ron Shnier and Warick Delprado and Thompson, {James T.} and Stricker, {Phillip D.} and Anant Madabhushi",

note = "Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = feb,

day = "1",

doi = "10.1038/srep41261",

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Rusu, M, Purysko, AS, Verma, S, Kiechle, J, Gollamudi, J, Ghose, S, Herrmann, K, Gulani, V, Paspulati, R, Ponsky, L, Bohm, M, Haynes, AM, Moses, D, Shnier, R, Delprado, W, Thompson, JT, Stricker, PD & Madabhushi, A 2017, 'Computational imaging reveals shape differences between normal and malignant prostates on MRI', Scientific Reports, vol. 7, 41261, pp. 1-11. https://doi.org/10.1038/srep41261

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T1 - Computational imaging reveals shape differences between normal and malignant prostates on MRI

AU - Rusu, Mirabela

AU - Purysko, Andrei S.

AU - Verma, Sadhna

AU - Kiechle, Jonathan

AU - Gollamudi, Jay

AU - Ghose, Soumya

AU - Herrmann, Karin

AU - Gulani, Vikas

AU - Paspulati, Raj

AU - Ponsky, Lee

AU - Bohm, Maret

AU - Haynes, Anne Maree

AU - Moses, Daniel

AU - Shnier, Ron

AU - Delprado, Warick

AU - Thompson, James T.

AU - Stricker, Phillip D.

AU - Madabhushi, Anant

N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p <0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.

AB - We seek to characterize differences in the shape of the prostate and the central gland (combined central and transitional zones) between men with biopsy confirmed prostate cancer and men who were identified as not having prostate cancer either on account of a negative biopsy or had pelvic imaging done for a non-prostate malignancy. T2w MRI from 70 men were acquired at three institutions. The cancer positive group (PCa+) comprised 35 biopsy positive (Bx+) subjects from three institutions (Gleason scores: 6-9, Stage: T1-T3). The negative group (PCa-) combined 24 biopsy negative (Bx-) from two institutions and 11 subjects diagnosed with rectal cancer but with no clinical or MRI indications of prostate cancer (Cl-). The boundaries of the prostate and central gland were delineated on T2w MRI by two expert raters and were used to construct statistical shape atlases for the PCa+, Bx- and Cl- prostates. An atlas comparison was performed via per-voxel statistical tests to localize shape differences (significance assessed at p <0.05). The atlas comparison revealed central gland hypertrophy in the Bx- subpopulation, resulting in significant volume and posterior side shape differences relative to PCa+ group. Significant differences in the corresponding prostate shapes were noted at the apex when comparing the Cl- and PCa+ prostates.

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U2 - 10.1038/srep41261

DO - 10.1038/srep41261

M3 - Article

C2 - 28145532

SN - 2045-2322

VL - 7

SP - 1

EP - 11

JO - Scientific Reports

JF - Scientific Reports

M1 - 41261

ER -

Computational imaging reveals shape differences between normal and malignant prostates on MRI

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