TY - JOUR
T1 - Computational investigation of stenosis in curvature of coronary artery within both dynamic and static models
AU - Biglarian, Mohit
AU - Larimi, Morsal Momeni
AU - Afrouzi, Hamid Hassanzadeh
AU - Moshfegh, Abouzar
AU - Toghraie, Davood
AU - Javadzadegan, Ashkan
AU - Rostami, Sara
PY - 2020/3
Y1 - 2020/3
N2 - Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both percentages of stenosis the maximum wall shear stress will accrue in the middle of the stenosis; however it is much more in the higher rate of stenosis. Conclusions: A chaotic wall shear stress region is also observed downstream of stenosis in the severe stenosis case. Finally it concluded that the arterial wall motion affects the wall shear stress and the plaque formation site.
AB - Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both percentages of stenosis the maximum wall shear stress will accrue in the middle of the stenosis; however it is much more in the higher rate of stenosis. Conclusions: A chaotic wall shear stress region is also observed downstream of stenosis in the severe stenosis case. Finally it concluded that the arterial wall motion affects the wall shear stress and the plaque formation site.
KW - Atherosclerosis
KW - Coronary artery
KW - Pulsatile flow
KW - Stenosis
KW - Wall shear stress
UR - http://www.scopus.com/inward/record.url?scp=85074634918&partnerID=8YFLogxK
U2 - 10.1016/j.cmpb.2019.105170
DO - 10.1016/j.cmpb.2019.105170
M3 - Article
C2 - 31710988
AN - SCOPUS:85074634918
VL - 185
SP - 1
EP - 11
JO - Computer Methods and Programs in Biomedicine
JF - Computer Methods and Programs in Biomedicine
SN - 0169-2607
M1 - 105170
ER -