Computational investigation of stenosis in curvature of coronary artery within both dynamic and static models

Mohit Biglarian, Morsal Momeni Larimi, Hamid Hassanzadeh Afrouzi, Abouzar Moshfegh, Davood Toghraie, Ashkan Javadzadegan, Sara Rostami*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Background and Objective: Blood flow variation during cardiac cycle is the main mechanism of atherosclerotic development which is dependent on. Methods: The present work mainly tends to investigate stenosis effect in dynamic curvature of coronary artery. This paper presents numerical investigations on wall shear stress profiles in three-dimensional pulsatile flow through curved stenotic coronary arteries for both static and dynamic model. In order to do so, three-dimensional models related to the curved arteries with two degrees of stenosis (30% and 50%). Results: Lower amount of wall shear stress is found near the inner wall of artery distal to the plaque region (stenosis) and in both percentages of stenosis the maximum wall shear stress will accrue in the middle of the stenosis; however it is much more in the higher rate of stenosis. Conclusions: A chaotic wall shear stress region is also observed downstream of stenosis in the severe stenosis case. Finally it concluded that the arterial wall motion affects the wall shear stress and the plaque formation site.

    Original languageEnglish
    Article number105170
    Pages (from-to)1-11
    Number of pages11
    JournalComputer Methods and Programs in Biomedicine
    Volume185
    DOIs
    Publication statusPublished - Mar 2020

    Keywords

    • Atherosclerosis
    • Coronary artery
    • Pulsatile flow
    • Stenosis
    • Wall shear stress

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