Computer-aided design and fabrication of bio-mimetic materials and scaffold micro-structures

Yuhang Chen, Joseph Cadman, Shiwei Zhou, Qing Li

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

9 Citations (Scopus)

Abstract

Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.

Original languageEnglish
Title of host publicationAdvanced Materials Research
Place of PublicationStafa-Zurich, Switzerland ; Enfield, NH
PublisherTrans Tech Publications
Pages628-632
Number of pages5
Volume213
ISBN (Print)9783037850619, 3037850612
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event2011 International Conference on Advanced Material Research, ICAMR 2011 - Chongqing, China
Duration: 21 Jan 201123 Jan 2011

Publication series

NameAdvanced Materials Research
Volume213
ISSN (Print)10226680

Other

Other2011 International Conference on Advanced Material Research, ICAMR 2011
CountryChina
CityChongqing
Period21/01/1123/01/11

Keywords

  • Bio-mimetic materials
  • Computer-aided design (CAD)
  • Homogenization method
  • Scaffold
  • Solid free-form fabrication (SFF)
  • Tissue engineering

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