TY - GEN
T1 - Computer-aided design and fabrication of bio-mimetic materials and scaffold micro-structures
AU - Chen, Yuhang
AU - Cadman, Joseph
AU - Zhou, Shiwei
AU - Li, Qing
PY - 2011
Y1 - 2011
N2 - Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.
AB - Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.
KW - Bio-mimetic materials
KW - Computer-aided design (CAD)
KW - Homogenization method
KW - Scaffold
KW - Solid free-form fabrication (SFF)
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=79952377434&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/AMR.213.628
DO - 10.4028/www.scientific.net/AMR.213.628
M3 - Conference proceeding contribution
AN - SCOPUS:79952377434
SN - 9783037850619
SN - 3037850612
VL - 213
T3 - Advanced Materials Research
SP - 628
EP - 632
BT - Advanced Materials Research
PB - Trans Tech Publications
CY - Stafa-Zurich, Switzerland ; Enfield, NH
T2 - 2011 International Conference on Advanced Material Research, ICAMR 2011
Y2 - 21 January 2011 through 23 January 2011
ER -