Concise review: Alchemy of biology: generating desired cell types from abundant and accessible cells

Behshad Pournasr, Keynoush Khaloughi, Ghasem Hosseini Salekdeh, Mehdi Totonchi, Ebrahim Shahbazi, Hossein Baharvand

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

A major goal of regenerative medicine is to produce cells to participate in the generation, maintenance, and repair of tissues that are damaged by disease, aging, or trauma, such that function is restored. The establishment of induced pluripotent stem cells, followed by directed differentiation, offers a powerful strategy for producing patient-specific therapies. Given how laborious and lengthy this process can be, the conversion of somatic cells into lineage-specific stem/progenitor cells in one step, without going back to, or through, a pluripotent stage, has opened up tremendous opportunities for regenerative medicine. However, there are a number of obstacles to overcome before these cells can be widely considered for clinical applications. Here, we focus on induced transdifferentiation strategies to convert mature somatic cells to other mature cell types or progenitors, and we summarize the challenges that need to be met if the potential applications of transdifferentiation technology are to be achieved.

LanguageEnglish
Pages1933-1941
Number of pages9
JournalStem Cells
Volume29
Issue number12
DOIs
Publication statusPublished - 1 Dec 2011
Externally publishedYes

Fingerprint

Alchemy
Regenerative Medicine
Stem Cells
Induced Pluripotent Stem Cells
Cell Lineage
Maintenance
Technology
Wounds and Injuries
Therapeutics

Keywords

  • Epigenetics
  • Reprogramming
  • Transcription factor
  • Transdifferentiation

Cite this

Pournasr, Behshad ; Khaloughi, Keynoush ; Salekdeh, Ghasem Hosseini ; Totonchi, Mehdi ; Shahbazi, Ebrahim ; Baharvand, Hossein. / Concise review : Alchemy of biology: generating desired cell types from abundant and accessible cells. In: Stem Cells. 2011 ; Vol. 29, No. 12. pp. 1933-1941.
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Pournasr, B, Khaloughi, K, Salekdeh, GH, Totonchi, M, Shahbazi, E & Baharvand, H 2011, 'Concise review: Alchemy of biology: generating desired cell types from abundant and accessible cells', Stem Cells, vol. 29, no. 12, pp. 1933-1941. https://doi.org/10.1002/stem.760

Concise review : Alchemy of biology: generating desired cell types from abundant and accessible cells. / Pournasr, Behshad; Khaloughi, Keynoush; Salekdeh, Ghasem Hosseini; Totonchi, Mehdi; Shahbazi, Ebrahim; Baharvand, Hossein.

In: Stem Cells, Vol. 29, No. 12, 01.12.2011, p. 1933-1941.

Research output: Contribution to journalReview articleResearchpeer-review

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