Abstract
Background The purpose of this study was to compare survival and functional outcomes in patients with advanced oral cavity squamous cell carcinoma (SCC) treated with either surgery + adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CRT). Methods Patients treated with curative intent by either surgery + RT or concurrent CRT were identified over a 6-year period (2001-2007). Disease and functional outcomes were analyzed on an intention-to-treat basis. Results Fifty-four patients underwent surgical excision and received postoperative RT. Fifty patients underwent concurrent CRT. Overall survival (OS) and disease-specific survival (DSS) was significantly higher in the surgically treated group (p < .001). Long-term enteral feeding tube support was more commonly required in those treated with CRT, whereas osteoradionecrosis rates were comparable between the 2 groups. Conclusion Treatment by surgery + adjuvant RT for advanced oral cavity SCC resulted in better disease control than treatment with CRT. This supports traditional surgical treatment algorithms for oral cavity cancer.
Original language | English |
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Pages (from-to) | 518-523 |
Number of pages | 6 |
Journal | Head and Neck |
Volume | 37 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Externally published | Yes |
Keywords
- chemoradiotherapy
- feeding tube
- head and neck cancer
- organ preservation
- osteoradionecrosis