Confirmation of chromosome 9p linkage in familial melanoma

D. J. Nancarrow; G. J. Mann; E. A. Holland; G. J. Walker; S. C. Beaton; M. K. Walters; C. Luxford; J. M. Palmer; J. A. Donald; J. L. Weber; J. W. Fountain; R. F. Kefford; N. K. Hayward

Confirmation of chromosome 9p linkage in familial melanoma

D. J. Nancarrow, G. J. Mann, E. A. Holland, G. J. Walker, S. C. Beaton, M. K. Walters, C. Luxford, J. M. Palmer, J. A. Donald, J. L. Weber, J. W. Fountain, R. F. Kefford, N. K. Hayward^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies of deletions in melanomas, and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. We have carried out linkage analysis using the 9p markers IFNA and D9S126 in 26 Australian melanoma kindreds. Multipoint analysis gave a peak lod score of 4.43, 15 cM centromeric to D9S126, although a lod score of 4.13 was also found 15 cM telomeric of IFNA. These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval. No significant heterogeneity was found between families, when either pairwise or multipoint data were analyzed using HOMOG.

Original language	English
Pages (from-to)	936-942
Number of pages	7
Journal	American Journal of Human Genetics
Volume	53
Issue number	4
Publication status	Published - 1993
Externally published	Yes

Cite this

@article{b9dae2ddeddb417bbdfbeb03f1e4a365,

title = "Confirmation of chromosome 9p linkage in familial melanoma",

abstract = "Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies of deletions in melanomas, and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. We have carried out linkage analysis using the 9p markers IFNA and D9S126 in 26 Australian melanoma kindreds. Multipoint analysis gave a peak lod score of 4.43, 15 cM centromeric to D9S126, although a lod score of 4.13 was also found 15 cM telomeric of IFNA. These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval. No significant heterogeneity was found between families, when either pairwise or multipoint data were analyzed using HOMOG.",

author = "Nancarrow, {D. J.} and Mann, {G. J.} and Holland, {E. A.} and Walker, {G. J.} and Beaton, {S. C.} and Walters, {M. K.} and C. Luxford and Palmer, {J. M.} and Donald, {J. A.} and Weber, {J. L.} and Fountain, {J. W.} and Kefford, {R. F.} and Hayward, {N. K.}",

year = "1993",

language = "English",

volume = "53",

pages = "936--942",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "University of Chicago Press",

number = "4",

}

TY - JOUR

T1 - Confirmation of chromosome 9p linkage in familial melanoma

AU - Nancarrow, D. J.

AU - Mann, G. J.

AU - Holland, E. A.

AU - Walker, G. J.

AU - Beaton, S. C.

AU - Walters, M. K.

AU - Luxford, C.

AU - Palmer, J. M.

AU - Donald, J. A.

AU - Weber, J. L.

AU - Fountain, J. W.

AU - Kefford, R. F.

AU - Hayward, N. K.

PY - 1993

Y1 - 1993

N2 - Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies of deletions in melanomas, and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. We have carried out linkage analysis using the 9p markers IFNA and D9S126 in 26 Australian melanoma kindreds. Multipoint analysis gave a peak lod score of 4.43, 15 cM centromeric to D9S126, although a lod score of 4.13 was also found 15 cM telomeric of IFNA. These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval. No significant heterogeneity was found between families, when either pairwise or multipoint data were analyzed using HOMOG.

AB - Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies of deletions in melanomas, and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. We have carried out linkage analysis using the 9p markers IFNA and D9S126 in 26 Australian melanoma kindreds. Multipoint analysis gave a peak lod score of 4.43, 15 cM centromeric to D9S126, although a lod score of 4.13 was also found 15 cM telomeric of IFNA. These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval. No significant heterogeneity was found between families, when either pairwise or multipoint data were analyzed using HOMOG.

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M3 - Article

C2 - 8213823

AN - SCOPUS:0027507837

SN - 0002-9297

VL - 53

SP - 936

EP - 942

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 4

ER -

Confirmation of chromosome 9p linkage in familial melanoma

Abstract

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