Conformational regulation of substituted azepanes through selective monofluorination

Alpesh Ramanlal Patel, Graham Ball, Luke Hunter, Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by 1H NMR spectroscopy and computational modelling. A single fluorine atom, installed diastereoselectively, was found to bias the azepane ring to one major conformation for one diastereomer.

Original languageEnglish
Pages (from-to)3781-3785
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number23
Publication statusPublished - 2013

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