Conserved tegument protein complexes: essential components in the assembly of herpesviruses

Russell J. Diefenbach*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


One of the structural components of herpesviruses is a protein layer called the tegument. Several of the tegument proteins are highly conserved across the herpesvirus family and serve as a logical focus for defining critical interactions required for viral assembly. A number of studies have helped to elucidate a role for conserved tegument proteins in the process of secondary envelopment during the course of herpesviral assembly. This review highlights how these tegument proteins directly contribute to bridging the nucleocapsid and envelope of virions during secondary envelopment.

Original languageEnglish
Pages (from-to)308-317
Number of pages10
JournalVirus Research
Publication statusPublished - 2 Dec 2015
Externally publishedYes


  • Herpesviridae
  • Herpesvirus
  • HSV-1
  • Tegument
  • Assembly
  • Envelopment

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