Continuous microfluidic immunomagnetic cell separation

David W. Inglis; R. Riehn; R. H. Austin; J. C. Sturm

doi:10.1063/1.1823015

Continuous microfluidic immunomagnetic cell separation

David W. Inglis^*, R. Riehn, R. H. Austin, J. C. Sturm

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

328 Citations (Scopus)

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Abstract

We present a continuous-flow microfluidic device that enables cell by cell separation of cells selectively tagged with magnetic nanoparticles. The cells flow over an array of microfabricated magnetic stripes, which create a series of high magnetic field gradients that trap the magnetically labeled cells and alter their flow direction. The process was observed in real time using a low power microscope. The device has been demonstrated by the separation of leukocytes from whole human blood.

Original language	English
Pages (from-to)	5093-5095
Number of pages	3
Journal	Applied Physics Letters
Volume	85
Issue number	21
DOIs	https://doi.org/10.1063/1.1823015
Publication status	Published - Nov 2004
Externally published	Yes

Bibliographical note

Copyright (2004) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters, 85:21, 5093-5095 and may be found at http://dx.doi.org/10.1063/1.1823015.

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AU - Austin, R. H.

AU - Sturm, J. C.

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Continuous microfluidic immunomagnetic cell separation

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