Contribution of hyphenated CE-ICP/MS in metal/protein interactions studies

J. Chamoun, A. Hagège*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


By introducing a preliminary in-capillary pre-concentration step, CE-ICP/MS was applied to trace metal speciation in proteins. Emphasis was put on metal/protein interactions where CE-ICP/MS is demonstrated to provide informations concerning metal binding and metal exchanges occuring in proteins. Preliminary studies on the fate of several metals in the presence of a mixture of standard proteins were performed. Cadmium was shown to bind mainly to albumin and ceruloplasmin. Cobalt and nickel were detected only in carbonic anhydrase and ceruloplasmin in the mixture of proteins but also in albumin when injected alone.

Original languageEnglish
Pages (from-to)659-664
Number of pages6
JournalRadiochimica Acta
Issue number11
Publication statusPublished - 2005


  • Capillary electrophoresis
  • ICP/MS
  • Metal
  • Protein

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