Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.

LanguageEnglish
Article number2713
Pages1-11
Number of pages11
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 13 Jul 2018

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Liposomes
genes
delivery
drugs
platforms
Genes
X-Rays
Radiation
X rays
radiation
chemotherapy
Chemotherapy
Pharmaceutical Preparations
x rays
Drug Therapy
Singlet Oxygen
Photodynamic therapy
Photosensitizing Agents
Photochemotherapy
Radiotherapy

Bibliographical note

Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Cite this

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title = "Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation",
abstract = "Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.",
author = "Wei Deng and Wenjie Chen and Sandhya Clement and Anna Guller and Zhenjun Zhao and Alexander Engel and Goldys, {Ewa M.}",
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Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation. / Deng, Wei; Chen, Wenjie; Clement, Sandhya; Guller, Anna; Zhao, Zhenjun; Engel, Alexander; Goldys, Ewa M.

In: Nature Communications, Vol. 9, No. 1, 2713, 13.07.2018, p. 1-11.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Engel,Alexander

AU - Goldys,Ewa M.

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