TY - JOUR
T1 - Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation
AU - Deng, Wei
AU - Chen, Wenjie
AU - Clement, Sandhya
AU - Guller, Anna
AU - Zhao, Zhenjun
AU - Engel, Alexander
AU - Goldys, Ewa M.
N1 - Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2018/7/13
Y1 - 2018/7/13
N2 - Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.
AB - Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.
UR - http://www.scopus.com/inward/record.url?scp=85050026058&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/DE130100894
UR - http://purl.org/au-research/grants/arc/CE140100003
U2 - 10.1038/s41467-018-05118-3
DO - 10.1038/s41467-018-05118-3
M3 - Article
C2 - 30006596
AN - SCOPUS:85050026058
SN - 2041-1723
VL - 9
SP - 1
EP - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2713
ER -