Controlling self-assembly of diphenylalanine peptides at high pH using heterocyclic capping groups

Adam D. Martin, Jonathan P. Wojciechowski, Andrew B. Robinson, Celine Heu, Christopher J. Garvey, Julian Ratcliffe, Lynne J. Waddington, James Gardiner, Pall Thordarson

Research output: Contribution to journalArticle

24 Citations (Scopus)
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Abstract

Using small angle neutron scattering (SANS), it is shown that the existence of pre-assembled structures at high pH for a capped diphenylalanine hydrogel is controlled by the selection of N-terminal heterocyclic capping group, namely indole or carbazole. At high pH, changing from a somewhat hydrophilic indole capping group to a more hydrophobic carbazole capping group results in a shift from a high proportion of monomers to self-assembled fibers or wormlike micelles. The presence of these different self-assembled structures at high pH is confirmed through NMR and circular dichroism spectroscopy, scanning probe microscopy and cryogenic transmission electron microscopy.
Original languageEnglish
Article number43947
Pages (from-to)1-6
Number of pages6
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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