TY - JOUR
T1 - Convergence of interoception, emotion, and social cognition
T2 - a twofold fMRI meta-analysis and lesion approach
AU - Adolfi, Federico
AU - Couto, Blas
AU - Richter, Fabian
AU - Decety, Jean
AU - Lopez, Jessica
AU - Sigman, Mariano
AU - Manes, Facundo
AU - Ibáñez, Agustín
PY - 2017/3
Y1 - 2017/3
N2 - Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz., the orbitofrontal and inferior frontal gyri, the amygdala, and mid temporal lobe/subcortical structures). Second, we explored such domains in patients with fronto-insulo-temporal damage. Relative to controls, the patients showed behavioral impairments of interoception, emotional processing, and social cognition, with preservation of other cognitive functions. Convergent results from both studies offer direct support for a model of insular-frontotemporal regions integrating interoception, emotion, and social cognition.
AB - Guided by indirect evidence, recent approaches propose a tripartite crosstalk among interoceptive signaling, emotional regulation, and low-level social cognition. Here we examined the neurocognitive convergence of such domains. First, we performed three meta-analyses of functional magnetic resonance imaging studies to identify which areas are consistently coactivated by these three systems. Multi-level Kernel Density Analysis (MKDA) revealed major overlaps in the right anterior insular and frontotemporal regions (viz., the orbitofrontal and inferior frontal gyri, the amygdala, and mid temporal lobe/subcortical structures). Second, we explored such domains in patients with fronto-insulo-temporal damage. Relative to controls, the patients showed behavioral impairments of interoception, emotional processing, and social cognition, with preservation of other cognitive functions. Convergent results from both studies offer direct support for a model of insular-frontotemporal regions integrating interoception, emotion, and social cognition.
KW - stroke
KW - insula
KW - frontotemporal networks
KW - Multi-level Kernel Density Analysis
UR - http://www.scopus.com/inward/record.url?scp=85009183719&partnerID=8YFLogxK
U2 - 10.1016/j.cortex.2016.12.019
DO - 10.1016/j.cortex.2016.12.019
M3 - Article
C2 - 28088652
AN - SCOPUS:85009183719
SN - 0010-9452
VL - 88
SP - 124
EP - 142
JO - Cortex
JF - Cortex
ER -